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research A case report and literature review of delayed telogen effluvium after topical imiquimod use in treating a cervical high-grade squamous intraepithelial lesion
This paper reports a rare case of telogen effluvium in a young woman following intravaginal imiquimod use without other severe systemic adverse events, resolving gradually over nine months.
research NDA Submission of Vepdegestrant (ARV-471) to U.S. FDA: The Beginning of a New Era of PROTAC Degraders
This article discusses the development and clinical progress of PROTAC technology, particularly focusing on the New Drug Application for vepdegestrant, an estrogen receptor-targeting PROTAC, marking significant advancements in targeted protein degradation therapies.
research Patients' Illness Perception as a Tool to Improve Individual Disease Management in Primary Cutaneous Lymphomas
This study found that illness perception, as measured by the Revised Illness Perception Questionnaire, was significantly associated with health-related quality of life in patients with primary cutaneous T- and B-cell lymphomas.
research Baricitinib (Olumiant)
This review assessed the clinical and cost-effectiveness of baricitinib, an oral treatment for severe alopecia areata in adults, to inform Canadian reimbursement recommendations, excluding Quebec.
research A rare manifestation of STING-associated vasculopathy with onset in infancy: a case report
In this case report, the authors describe a child and his mother with a heterozygous STING variant linked to SAVI, who exhibited atypical disease courses and varying organ involvement, underlining the diverse clinical manifestations of SAVI.
research In Silico Structure-Based Drug Design Approach To Evaluate Quercetin And Kaempferol As Dual Inhibitors Of Jak3 Kinase And 5-Alpha Reductase Type II with ADMET Profiling
This study used molecular docking to analyze the binding affinities of quercetin and kaempferol, plant-derived flavonoids, showing they have promising interaction profiles with JAK3 kinase and moderate binding with 5-alpha reductase type 2, suggesting potential as topical treatments for androgenetic alopecia.
research Chloroquine and cinchonine affect rat vascular smooth muscle tonus through calcium channels – in silico and in vitro approaches
This study examined the vasorelaxant effects of two similar alkaloids, chloroquine and cinchonine, in a model of smooth muscle contractions induced by phenylephrine. Results are not reported in the abstract.
research Persistent scurvy after vitamin C supplementation in a high-risk patient: a case report
In this case study, scurvy was diagnosed in a middle-aged man on hemodialysis with food insecurity and undetectable vitamin C levels, highlighting the diverse risk factors and persistent challenges in managing vitamin C deficiency among patients with complex medical and social issues.
research Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer
This study found that the protein hairless acts as both a corepressor and coactivator of the vitamin D receptor, influencing gene transcription in a ligand-selective manner.
research Evaluation of Serum Ferritin, Creatinine and Liver Enzymes in Patients with ß- thalassemia After Administration of Deferasirox
In this study, researchers assessed the effects of deferasirox in 85 children with ß-thalassemia in Kirkuk and reported that while 55.3% experienced a reduction in serum ferritin, 9.4% had adverse effects, indicating that deferasirox is generally well-tolerated as an iron chelator with modifiable side effects.
research Hereditary Vitamin D Resistant Rickets: Clinical, Laboratory, and Genetic Characteristics of 2 Iranian Siblings
This study described the clinical and genetic features of two Iranian siblings with hereditary vitamin D resistant rickets, identifying a specific VDR gene mutation contributing to their symptoms.
research Preparation of a highly specific single chain variable fragment antibody targeting miroestrol and its application in quality control of Pueraria candollei by enzyme‐linked immunosorbent assay
This study developed a sensitive and precise scFv-based ELISA for miroestrol quantification, aiding quality control in P. candollei plant materials and health supplements.
research The incidental pore: CaV1.2 and stem cell activation in quiescent hair follicles
In their research, Yucel and colleagues found that CaV1.2 is expressed in hair follicle stem cells, facilitating anagen re-entry in a way not dependent on calcium flux.
research Keratosis pilaris with adjacent haemosiderin deposition: a clue to scurvy
This case report describes how a misleading presentation of a rash initially resembling vasculitis was ultimately diagnosed as scurvy through histological examination, revealing the importance of dietary history and histopathology in differential diagnosis.
research 27604 Response to baricitinib in the treatment of patients with early and late onset alopecia areata in the phase 2 portion of BRAVE-AA1 randomized controlled trial
This study evaluates the effectiveness and safety of 2-mg and 4-mg doses of baricitinib in patients with alopecia areata who have lost at least 50% of their scalp hair, comparing outcomes between those with early and late onset of the disease.
research RASopathic alopecia: Hair changes associated with vemurafenib therapy
In this study, five out of six patients treated with vemurafenib for metastatic melanoma experienced hair loss, which improved after topical steroid treatment.
research In Silico Structure-Based Drug Design Approach To Evaluate Quercetin And Kaempferol As Dual Inhibitors Of Jak3 Kinase And 5-Alpha Reductase Type II with ADMET Profiling
In this study, quercetin and kaempferol, two plant-derived flavonoids, showed stronger binding affinities to JAK3 kinase and moderate binding to 5-alpha reductase type 2, suggesting their potential as natural treatments for androgenetic alopecia, with quercetin demonstrating suitable properties for topical application.
research Health-related quality of life in adult Mediterranean women with polycystic ovary syndrome attending to a tertiary hospital: a case-control study.
This study reported that health-related quality of life was significantly lower in adult Mediterranean women with PCOS and the anovulatory phenotype compared to controls at a tertiary hospital.
research Topical minoxidil improves the quality of life in female with androgenetic alopecia
In this study, topical minoxidil significantly improved the quality of life for females with androgenic alopecia, as measured by both the dermatology life quality index and a visual analog scale.
research Translation into Portuguese language (Brazil), transcultural adaptation and validation of the quality of life questionnaire in female pattern hair loss (WAA-QoL-BP)
Researchers translated and validated the WAA-QoL questionnaire into Brazilian Portuguese, finding it to be a reliable tool for assessing quality of life in women with female pattern hair loss.
research Efluvio telógeno: uma sequela pos-COVID 19
This study's systematic review found that many individuals recovering from COVID-19 experience high rates of telogen effluvium, a common form of hair loss, highlighting limited epidemiological data and the need for further investigation into this condition post-COVID-19.
research Quantification of Riboflavin and Thiamine in GI (Geographical Indication) Branded Yogurts Collected from Bogura, Bangladesh Using HPLC Equipped with a Fluorescence Detector
This study measured the amounts of thiamine and riboflavin in Bogura's Geographical Indication branded yogurt and whey, finding them rich in these vitamins, which are beneficial for health.
research Exome analysis for Cronkhite-Canada syndrome: A case report
In this study, researchers found multiple somatic mutations and copy number variations in a patient with Cronkhite-Canada syndrome, providing novel insights into its potential genetic mechanisms.
research Queen Anne sign
This case report describes a 72-year-old man who developed symptoms of fatigue and cold intolerance after discontinuing his levothyroxine treatment for hypothyroidism six months earlier.
research Reliability and validity of a measure to assess the health-related quality of life of women with alopecia areata
This study validated the Women's Androgenetic Alopecia Quality of Life questionnaire as a reliable and valid measure of health-related quality of life in women with alopecia areata.
research Correlation of symptoms to serum vitamin D levels?
This study among ethnic Saudi Arabian women concluded that symptoms like muscle cramps, fatigue, mood swings, hair loss, back pain, and weight gain were more common in those with lower vitamin D levels.
research 04094 Quality of care and risk of relapse in porphyria cutanea tarda: a study from the Norwegian porphyria registry
In this study, Norwegian researchers followed over 350 patients with porphyria cutanea tarda for an average of 7 years and found that 25% experienced biochemical relapse, suggesting the importance of routine follow-up for early detection and management.
research INTEGRATIVE APPROACH TO KHALITYA: BRIDGING AYURVEDA AND MODERN SCIENCE
In this observational study, researchers found that 55% of participants with hair loss known as Khalitya had serum calcium deficiency, which aligns with both Ayurvedic and modern perspectives linking poor nutrition to hair disorder, highlighting the importance of dietary regulation and stress management.