Queen Anne Sign in a 72-Year-Old Man with Hypothyroidism

    February 2022 in “ Canadian Medical Association Journal ”
    Jane Kobylianskii, Wayne L. Gold
    TLDR Severe hypothyroidism can cause eyebrow hair loss, but improves with thyroid hormone treatment.
    A 72-year-old man with a history of hypothyroidism presented with symptoms including fatigue, cold intolerance, and loss of the outer third of his eyebrows, known as the Queen Anne sign. He had discontinued levothyroxine 6 months prior, leading to severe hypothyroidism, evidenced by elevated thyrotropin levels and undetectable thyroid hormones. Despite concerns for myxedema coma, psychiatric evaluation did not support this, and his condition improved with oral thyroid hormone replacement. The Queen Anne sign, though uncommon, was attributed to his hypothyroidism. Severe hypothyroidism is rare in Canada due to accessible testing and treatment, but if untreated, it can lead to serious complications.
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