TLDR Albumin and prednisone improved symptoms in a woman with Cronkhite-Canada syndrome, revealing potential genetic causes.
Cronkhite-Canada syndrome (CCS) is a rare disorder characterized by gastrointestinal polyps and ectodermal lesions, including alopecia. This case report describes an elderly female with CCS who experienced significant symptom improvement with albumin supplementation and prednisone. Exome sequencing of her colorectal adenoma revealed novel somatic mutations in USP24, KCNQ5, and FKBP10 genes, and elevated copy numbers in HPSE2, SPATA7, and ZC3H18 genes, suggesting potential genetic mechanisms underlying CCS. Further research with larger sample sizes is needed to confirm these findings and understand the disease's etiology.
16 citations
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May 2013 in “Australasian Journal of Dermatology” Hair loss in Cronkhite-Canada syndrome is reversible by treating the gut issues and doesn't need steroid treatment for the hair itself.
October 2013 in “The American Journal of Gastroenterology” The man's diarrhea was caused by a rare disorder called Cronkhite-Canada syndrome, which improved with specific medications.
May 2002 in “Australasian Journal of Dermatology” Finasteride is effective for male hair loss, teledermatology is accurate and accepted, and cyclosporin helps treat toxic epidermal necrolysis.
January 2022 in “Gastro Hep advances” Prednisone treatment helped a woman with Cronkhite-Canada syndrome recover from hair loss and digestive issues.
6 citations
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November 2018 in “Case reports in nephrology and dialysis” Rituximab may be an effective treatment for Cronkhite-Canada syndrome with kidney disease.
October 2024 in “Medicine” Cronkhite-Canada syndrome is rare, has a poor prognosis, and requires early diagnosis and ongoing treatment.
