A Very Unusual Cause of Diarrhea in a 60-Year-Old Man
October 2013
in “
The American Journal of Gastroenterology
”
Studysummary This case study reports a diagnosis of the rare Cronkhite-Canada syndrome in a 60-year-old man, who showed symptom improvement following treatment with prednisone and azathioprine.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
A 60-year-old man was diagnosed with Cronkhite-Canada syndrome (CCS), a rare non-hereditary disorder characterized by symptoms such as diarrhea, weight loss, nail and hair loss (alopecia), decreased taste sensation, and skin hyperpigmentation. The diagnosis was supported by findings of diffuse gastrointestinal polyps and mucosal abnormalities. CCS is associated with a 25% lifetime risk of colorectal cancer and a high mortality rate due to protein-losing enteropathy. Treatment with prednisone and azathioprine led to symptom improvement. Although no standardized treatment exists, corticosteroids and azathioprine have shown positive results, and resection of remaining polyps is recommended to prevent potential dysplastic changes.
