An Unusual Case of Diarrhea, Dysgeusia, and Grainy and Nodular Mucosa

A 78-year-old man presented with diarrhea, dysgeusia, skin pigmentation, alopecia, and weight loss, leading to a diagnosis of Cronkhite-Canada Syndrome (CCS) after extensive diagnostic work-up. CCS is a rare, noninherited disease characterized by gastrointestinal polyposis, hair loss, nail dystrophy, and skin hyperpigmentation. The patient was treated with prednisone, gastric mucosal protective agents, proton pump inhibitors, calcium tablets, and probiotics. Over 16 weeks, his symptoms improved significantly, including the resolution of gastrointestinal lesions and regrowth of hair and nails. The patient remains asymptomatic and continues regular follow-up.