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![The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed](/images/research/87f5ad9c-9c02-465a-81b4-397b66f4b25a/small/30955.jpg)
research The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed
The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
![Melatonin membrane receptors in peripheral tissues: Distribution and functions](/images/research/fae5a9a1-a612-40f8-a864-e0942104363c/small/14663.jpg)
research Melatonin membrane receptors in peripheral tissues: Distribution and functions
Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.
![Keratins in health and cancer: more than mere epithelial cell markers](/images/research/18592881-c07d-41cc-b603-b131e21a554e/small/29324.jpg)
research Keratins in health and cancer: more than mere epithelial cell markers
Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.
![The Browning of White Adipose Tissue: Some Burning Issues](/images/research/f47a6a45-c466-4924-8047-7c145abee56e/small/34914.jpg)
research The Browning of White Adipose Tissue: Some Burning Issues
Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.
![Regeneration of fat cells from myofibroblasts during wound healing](/images/research/2aa9b36e-b3d7-4658-9925-da3d5589e0e7/small/19564.jpg)
research Regeneration of fat cells from myofibroblasts during wound healing
Some wound-healing cells can turn into fat cells around new hair growth in mice.
![Overweight and Obesity in Children and Adolescents](/images/research/93191251-e2fa-4181-85a3-46e99ddb06f2/small/14373.jpg)
research Overweight and Obesity in Children and Adolescents
Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.
![Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome](/images/research/037cd2cb-63ed-4fdf-b2bf-a4b39f6cfc17/small/14833.jpg)
research Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome
Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.
![Alopecia areata: a review of disease pathogenesis](/images/research/22fb9ced-e19a-4eed-8a67-a6abe5ec115b/small/30110.jpg)
research Alopecia areata: a review of disease pathogenesis
Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.
![The PDGF/PDGFR pathway as a drug target](/images/research/0473bdc0-2467-428e-956c-29d8eaf0001f/small/22624.jpg)
research The PDGF/PDGFR pathway as a drug target
The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.
![The Harmonies Played by TGF-β in Stem Cell Biology](/images/research/3f7bbf60-99e7-42b4-9a69-143b69ad55ac/small/19812.jpg)
research The Harmonies Played by TGF-β in Stem Cell Biology
TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.
![The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside](/images/research/ae023163-52f0-4aa6-a6ae-bb3a052be231/small/34716.jpg)
research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside
Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.
![What’s Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses](/images/research/d936d4e0-7ec4-4024-8f2c-e61287fb63aa/small/17421.jpg)
research What’s Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses
Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.
![Cepharanthine: An update of its mode of action, pharmacological properties and medical applications](/images/research/e8d4c634-fcfd-4cf1-acb1-c6465aee543c/small/32055.jpg)
research Cepharanthine: An update of its mode of action, pharmacological properties and medical applications
Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.
![Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management](/images/research/b6a06b26-2a2d-4b11-9506-d7f023d4662e/small/31534.jpg)
research Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management
Restoring hair bulb immune privilege is crucial for managing alopecia areata.
![A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity](/images/research/4fca6c7a-15bb-4b29-ac99-93890fc4043b/small/20447.jpg)
research A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity
A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.
![Physiologic functions of PP2A: Lessons from genetically modified mice](/images/research/ac8b0de1-9a02-4440-bd99-daee7b61ba45/small/19383.jpg)
research Physiologic functions of PP2A: Lessons from genetically modified mice
Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.
![Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion](/images/research/efb33c2a-6422-4511-b1ef-3492b17cdd28/small/31163.jpg)
research Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion
The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.
![Red ginseng monograph](/images/research/6ff38ca8-2735-47d0-be4b-bf82fcc2b1c4/small/20202.jpg)
research Red ginseng monograph
Red ginseng may improve immunity, fatigue, memory, blood circulation, and menopausal symptoms, and is generally safe to consume.
![Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness](/images/research/ed924df4-8bfb-4e7a-9bf1-e2fe9eddf220/small/30881.jpg)
research Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness
Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.
![A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice](/images/research/1aa25012-93a3-4c11-8b1c-5a14b6915747/small/28445.jpg)
research A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice
Scientists found a gene in mice that causes early hearing loss.
![Symbiotic in vitro seed propagation of Dendrobium: fungal and bacterial partners and their influence on plant growth and development](/images/research/91b5c45c-4675-4420-bd87-723e71c95671/small/23071.jpg)
research Symbiotic in vitro seed propagation of Dendrobium: fungal and bacterial partners and their influence on plant growth and development
Certain fungi and bacteria help orchid seeds germinate and plants grow better.
![Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for <i>In Vivo</i> CRISPR/Cas-Based Genome Editing](/images/research/e4a37d59-bf0a-416b-bedb-644daadcb099/small/20857.jpg)
research Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing
Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.
![Recent advances in nanocarrier-loaded gels: Which drug delivery technologies against which diseases?](/images/research/76cf5700-b944-4ef7-9215-2ecdf9bd2294/small/34332.jpg)
research Recent advances in nanocarrier-loaded gels: Which drug delivery technologies against which diseases?
Nanocarrier-loaded gels improve drug delivery for cancer, skin conditions, and hair loss.
![Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options](/images/research/d1745252-b913-4925-979f-d412b360fd65/small/26852.jpg)
research Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options
The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.
![Bacteria induce skin regeneration via IL-1β signaling](/images/research/6140b738-04c9-4fe0-b954-ba271813e9df/small/12666.jpg)
research Bacteria induce skin regeneration via IL-1β signaling
Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.
![Bioengineered Plants Can Be a Useful Source of Omega-3 Fatty Acids](/images/research/3fb39e7c-fc3f-4070-8ef8-16cc8af4b36f/small/27146.jpg)
research Bioengineered Plants Can Be a Useful Source of Omega-3 Fatty Acids
Genetically modified plants could be an important source of omega-3 fats to meet global needs.
![The Spectrum of Scarring in Craniofacial Wound Repair](/images/research/66954183-308a-4664-bd90-9e9a5766c3d3/small/12700.jpg)
research The Spectrum of Scarring in Craniofacial Wound Repair
Wounds on the face usually heal with scars, but understanding how some wounds heal without scars could lead to better treatments.
![The Human Skin Microbiome in Selected Cutaneous Diseases](/images/research/140f9056-1fed-4b3f-a362-2e9f97d79d7e/small/29977.jpg)
research The Human Skin Microbiome in Selected Cutaneous Diseases
Changes in skin microbes play a role in some skin diseases and could lead to new treatments.
![Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart](/images/research/b1c36f06-8e61-4175-bb0b-02926624f306/small/17470.jpg)
research Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart
The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.