research Past and Future Strategies for GPCR Deorphanization
Finding functions for unknown GPCRs is hard but key for making new drugs.
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research Effects of Minoxidil on Cultured Human Skin Fibroblasts
Minoxidil slows down skin cell growth and may help treat scars and skin conditions.
research Tracing the Cellular Origin of Cancer
Understanding where cancer cells come from helps create better prevention and treatment methods.
research The Circadian Molecular Clock Creates Epidermal Stem Cell Heterogeneity
The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.
research Alpha-Parvin Is Required for Epidermal Morphogenesis, Hair Follicle Development, and Basal Keratinocyte Polarity
α-parvin is necessary for skin and hair growth and for the correct orientation of skin cells.
research Nuclear Factor (Erythroid-Derived 2)-Like-2 Pathway Modulates Substance P–Induced Human Mast Cell Activation and Degranulation in the Hair Follicle
Activating the Nrf2 pathway reduces inflammation and cell activation in human hair follicles, suggesting a potential treatment for certain hair loss conditions.
research Age- and Sex-Dependence of Five Major Elements in the Development of Human Scalp Hair
Calcium and magnesium in hair increase with age and are higher in adult women.
research Structure Optimization of Tetrahydropyridoindole-Based Aldose Reductase Inhibitors Improved Their Efficacy and Selectivity
Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.
research Eosinophilic Pleural Effusion Due to Topical Minoxidil Use
A woman's use of minoxidil for hair loss caused fluid buildup in her chest, which went away when she stopped using the product.
research Dermal White Adipose Tissue Development and Metabolism: The Role of Transcription Factor Foxn1
Foxn1 is important for fat development, metabolism, and wound healing in skin.
research BRCA2 in Abscission: Role in Cytokinesis and Recruitment of Abscission Regulators
The tumor suppressor BRCA2 helps in cell division by bringing key proteins to the area where cells split.
research Pericardial Disorders During Open-Label Study of 1,869 Severely Hypertensive Patients Treated with Minoxidil
Minoxidil doesn't increase pericardial disorder risk, but may cause fluid accumulation.
research Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites
The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
research Edematous Striae Distensae in a 14-Year-Old Girl with Nephrotic Syndrome
The girl's swelling and skin issues improved with fluid restriction and diuretics.
research Transgenic Endothelin 3 Regulates Murine Pigment Production and Coat Color
The gene Endothelin 3 makes mice's fur darker by increasing pigment cells and pigment levels.
research Hair, Cutaneous Homeostasis, and Stem Cell Functions
Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.
research Tryptophan in Human Hair: Correlation with Pigmentation
Men have more tryptophan in their hair than women, and it increases with age and is higher in darker and grey or white hair.
research An X-Linked Gene Involved in Androgenetic Alopecia: A Lesson to Be Learned from Adrenoleukodystrophy
Gene linked to common hair loss found, may lead to new treatments.
research Isotretinoin Treatment Upregulates the Expression of P53 in the Skin and Sebaceous Glands of Patients with Acne Vulgaris
Acne treatment with isotretinoin increases the presence of p53, a protein, in skin and oil glands, which may help reduce acne severity.
research Restoration of Hair Follicle Inductive Properties by Depletion of Senescent Cells
Removing senescent cells can improve hair growth and regeneration.
research Hyaluronic Acid-FGF2-Derived Peptide Bioconjugates for Suppression of FGFR2 and AR Simultaneously as an Acne Antagonist
The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.
research Fabrication and Evaluation of Vitamin-Doped ZnO/AgNPs Nanocomposite Based Wheat Gluten Films: Promising Findings for Burn Wound Treatment
The nanocomposite films with vitamins and nanoparticles are promising for fast and effective burn wound healing.
research Part II: Common Questions and Misconceptions About Creatine Supplementation: What Does the Scientific Evidence Really Show?
Creatine monohydrate is safe and effective for muscle recovery and performance, especially for those with low creatine levels.
research Premature Aging Syndromes: From Patients to Mechanism
Studying premature aging syndromes helps understand human aging and suggests potential treatments.
research Writer’s Cramp Presentation of Woodhouse–Sakati Syndrome – Out of the Woods
Woodhouse-Sakati syndrome can cause writer's cramp and other varied symptoms, highlighting the importance of genetic testing for diagnosis.
research Induction of Versican by Ascorbic Acid 2-Phosphate in Dermal Papilla Cells
Vitamin C derivative increases versican in cells, potentially aiding hair growth.
research Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice
Genetic mutations that disrupt homocysteine breakdown lead to increased damage in mouse hair keratin.
research Scanning Electron Microscopes/Silicon Drift Detector-Energy Dispersive Spectroscopy: An Analytical Tool to Identify Waterborne Microminerals Pickup in Human Scalp Hair Cuticle Due to Water Quality
The method can identify minerals in hair from water, and using coconut oil or conditioner can prevent mineral buildup.
research Retinoids Modulate MITF: A Novel Mechanism in the Regulation of Melanogenesis
Retinoids or their analogs could treat skin pigmentation disorders like melasma and vitiligo.
research The Important Role of Leptin in Modulating the Risk of Dermatological Diseases
Leptin, a hormone from fat cells, affects immune responses and can influence skin diseases and hair growth.