research Preparation of 3H-Labelled Testosterone Metabolites
The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.
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research Probing Androgen Receptor Co-Factor Selectivity Profiles: A Chemical Tool to Determine Cross-Talk Between Androgen Receptor and Beta-Catenin In Vivo
PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.
research Features of Hyperandrogenism in Men
Androgen levels can increase at any age, affecting symptoms like acne, hair loss, and prostate size.
research Clinical Pearls in Men's Health
The conclusion is that individualized treatment and proper medication use are crucial in men's health, with specific recommendations for ED, BPH, and prostate cancer management.
research High-Performance Liquid Chromatographic Determination of the Enantiomers of the Benzoquinolinone LY 191704, a Human Type 1 5α-Reductase Inhibitor, in Plasma
Researchers developed a method to measure different forms of a drug that could help treat prostate issues and hair loss, and found how these forms behave in animals.
research Trapa Bispinosa Roxb. Pericarp Extract Exerts 5α-Reductase Inhibitory Activity in Castrated Benign Prostatic Hyperplasia Model Mice
Trapa bispinosa Roxb. extract may help reduce prostate size and cell growth in BPH.
research Analysis of Benign Prostatic Obstruction Surgery: A Long-Term Evaluation in a Real-Life Context
Prostate surgery is often effective long-term, but some patients may need more treatment or another surgery, especially if they had prostatitis before.
research Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides and Their Effect on 5α-Reductase Isoform 2, Androgen Receptor, and Androgen-Dependent Glands
New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.
research In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands
Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.
research Decision Letter: Effects of Lifelong Testosterone Exposure on Health and Disease Using Mendelian Randomization
Increased free testosterone can lead to stronger bones and less body fat but also higher risks of prostate cancer, hair loss, spine issues, and high blood pressure.
research Effects of Finasteride Use on Prostate Volume and Serum PSA Levels in Young Patients
Finasteride reduces prostate size and PSA levels in young patients.
research Effect of Hydroethanolic Extract of Coffea Arabica L. Seeds on Induced Prostatic Hyperplasia in Orchiectomized Swiss Mice
Low doses of Coffea arabica seed extract prevent prostate growth and lower uric acid and PSA levels.
research Early-Onset Male Androgenetic Alopecia Associated with Prostate Cancer
Early baldness in men may indicate a higher risk of prostate cancer.
research Early-Onset Male Androgenetic Alopecia Associated with Prostate Cancer
Early-onset male baldness may indicate a higher risk of prostate cancer.
research A Clinicopathologic Study of Lichen Planopilaris Among Men
Most men with lichen planopilaris had it confirmed by biopsy and often had thyroid issues, sexual dysfunction, or prostate cancer, hinting at a link with hormonal problems.
research Minimal Systemic Exposure of a New Topical Triazole Antifungal, Efinaconazole 10% Solution, in Patients with Severe Onychomycosis Following 28-Day Treatment
Hair loss is a common but often unreported side effect of cancer treatments, especially for breast and prostate cancers.
research Incidence of Alopecia from Endocrine Therapies in Cancer
Hair loss is a common, often overlooked side effect of hormone treatments for breast and prostate cancer.
research Intervention in Prostate Cancer: Slight Advantages for Radical Prostatectomy
Men with early balding may have a higher risk of prostate issues, and surgery for prostate cancer has a slight survival benefit over radiation.
research Baldness In Young Men Could Be A Risk Factor For BPH
Early balding may be a sign of future prostate problems.
research Urinary PSA: Marker of Benign Prostatic Hyperplasia?
Urinary PSA could be an early marker for enlarged prostate.
research News in Brief
Breast cancer survivors may have a higher risk of falls, tamoxifen could prevent breast cancer and deaths, new guidelines urge caution with prostate cancer therapy, and early balding in men may indicate a higher prostate cancer risk.
research S2 PSA: Reliable or Not Reliable?
PSA testing is a reliable method for detecting prostate cancer, and opioids may lower PSA levels, but triglycerides don't affect prostate cancer risk.
research Urethral PSA Levels After Radical Prostatectomy
Higher urethral PSA levels after prostate removal surgery may be linked to more hair loss and higher PSA levels post-surgery.
research Crystal Structure and Synthesis of 17α-Acetoxy-Pregn-4,6-Diene-3,20-Dione
The compound was successfully made and shows potential for treating prostate cancer.
research Does PSADT After Radical Prostatectomy Predict Overall Survival?—A Report from the SEARCH Database Group
Shorter PSADT after prostate surgery is linked to higher risk of death.
research The Role of Dutasteride in the Treatment of Benign Prostatic Obstruction and Related Conditions
Dutasteride effectively treats benign prostatic obstruction, improves urinary flow, reduces prostate size, and may prevent prostate cancer, but can cause sexual side effects.
research 17α-Acetoxy-6-Bromo-16β-Methylpregna-4,6-Diene-3,20-Dione: A New Steroidal Derivative with High Antiandrogenic Activity
A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.
research Synthesis, Characterization and Evaluation of 5α, 6β-Dihalo Androsterone Derivatives as 5α-Reductase Inhibitors
Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.
research Modulation of Heat Sensitivity in Prostate Cancer In Vitro: The Influence of the Androgen Axis
Androgen-modulating drugs do not significantly change the heat sensitivity of prostate cancer cells.
research How to Deal with the Issues of Fertility, Malignancies, and Postfinasteride Syndrome While Prescribing Finasteride for Male Pattern Hair Loss
Finasteride is effective for male hair loss, but it may cause fertility issues, mental health problems, and rarely, breast growth. Regular health checks can reduce the risk of prostate cancer. Patient understanding and involvement in treatment is important.