Clinical Outcomes of High-Risk Prostate Adenocarcinoma (T3 and Gleason Score ≥8)
September 2009
in “
European Urology Supplements
”
TLDR Surgery for high-risk prostate cancer is challenging but doesn't lead to more complications, and additional treatment is often needed.
The document reports on the clinical outcomes of high-risk prostate adenocarcinoma, specifically in patients with a Gleason score of ≥8 and stage T3. Fifteen patients were included in the study, with an age range of 51-74 years and a mean follow-up of 22.1 months. The study found that surgery in high-risk patients did not increase morbidity despite being technically more difficult. Complications included positive surgical margins in 6 patients, lymph node involvement in 1, seminal vesicle involvement in 5, incontinence in 3, and stricture in 3 patients. Adjuvant treatment was often required, but no hormonal resistance developed, and no PSA relapse occurred in 3 patients without adjuvant treatment during follow-ups. No deaths were reported during the follow-up period. The study concludes that while surgery for high-risk prostate adenocarcinoma patients is more challenging, it does not necessarily lead to increased morbidity, and adjuvant treatment is frequently necessary.
