Urethral PSA Production After Radical Prostatectomy

September 2009 in “ European Urology Supplements ”

T. Pejcic, N. Lalic, B. Glisic, C. Tulic, B. Milkovic, Jovan Hadzi-Djokic

urethral prostate-specific antigen uPSA radical prostatectomy prostate cancer androgenic alopecia AGA dihydrotestosterone DHT PSA RP

TLDR After prostate removal surgery, higher initial prostate size was linked to higher urethral PSA levels and more severe male pattern baldness.

The study investigated the average urethral prostate-specific antigen (uPSA) production in 45 patients who had undergone radical prostatectomy (RP) for prostate cancer and sought to identify influencing factors. It was found that the average postoperative uPSA level was 18.9±40.1 ng/ml. The patients were categorized based on prostate volume, with significant differences noted in postoperative PSA values, postoperative uPSA, and the grade of androgenic alopecia (AGA) between the two groups. Higher prostate volume prior to RP was associated with higher postoperative PSA and uPSA levels, as well as a higher grade of AGA, suggesting a link with local dihydrotestosterone (DHT) activity.

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Related Research

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research Is Radical Prostatectomy the Best Choice for Patients with Locally Advanced Prostate Cancer?

September 2010 in “European Urology Supplements”

The document does not confirm if radical prostatectomy is the best treatment for locally advanced prostate cancer.