Urethral PSA Production After Radical Prostatectomy

    September 2009 in “ European Urology Supplements ”
    T. Pejcic, N. Lalic, B. Glisic, C. Tulic, B. Milkovic, Jovan Hadzi-Djokic
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    TLDR After prostate removal surgery, higher initial prostate size was linked to higher urethral PSA levels and more severe male pattern baldness.
    The study investigated the average urethral prostate-specific antigen (uPSA) production in 45 patients who had undergone radical prostatectomy (RP) for prostate cancer and sought to identify influencing factors. It was found that the average postoperative uPSA level was 18.9±40.1 ng/ml. The patients were categorized based on prostate volume, with significant differences noted in postoperative PSA values, postoperative uPSA, and the grade of androgenic alopecia (AGA) between the two groups. Higher prostate volume prior to RP was associated with higher postoperative PSA and uPSA levels, as well as a higher grade of AGA, suggesting a link with local dihydrotestosterone (DHT) activity.
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