Image Guided Radiotherapy in Stage III Prostate Cancer: Analysis of Acute Toxicity

    September 2009 in “ European Urology Supplements ”
    E. Mazzeo, Giovanna Mantini, V. Frascino, Gian Carlo Mattiucci, N. Dinapoli, S. Fersino, Luca Tagliaferri, Alessio Giuseppe Morganti, C. Rinaldi, E. Ciurlia, S. Luzi, Numa Cellini
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    TLDR IGRT resulted in lower acute toxicity for stage III prostate cancer patients.
    The study from 2009 evaluated the effectiveness of Image-Guided Radiation Therapy (IGRT) in reducing acute toxicity for 84 patients with stage III prostate cancer undergoing intensity-modulated radiotherapy (IMRT). It compared 12 patients who received IGRT with 72 who did not. The results showed that all patients in the IGRT group experienced only low-grade (Grade 0-1) gastrointestinal and genitourinary toxicities, while in the non-IGRT group, 94% had low-grade gastrointestinal toxicity with 6% experiencing higher-grade (Grade 2-3) toxicity, and 85% had low-grade genitourinary toxicity with 15% developing higher-grade toxicity. The study concluded that IGRT, by allowing for smaller margins and lower doses to surrounding organs, resulted in lower clinical toxicities.
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