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PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Low selenium levels can extend lifespan but worsen health issues.

Fat-derived stem cells show promise for treating skin issues and improving wound healing, but more research is needed to confirm the best way to use them.

Odontogenic keratocysts are caused by abnormal Hedgehog signaling and can lead to tooth and bone issues.

Post-finasteride syndrome causes lasting sexual, mental, and physical issues, needing more research for solutions.

Certain pesticides and fungicides can interfere with male hormone functions, potentially causing reproductive issues in male rats.

There's a significant link between severe hair loss and metabolic syndrome in Saudi Arabia, suggesting early health checks could prevent future issues.

Androgenetic alopecia is linked to heart disease, metabolic issues, and mental health problems.

New treatments for male hypogonadism are effective and should be personalized.

Combination therapy improves urinary flow and reduces residual urine, but needs better stent design.

Finasteride use varies among Denmark, Finland, Norway, and Sweden, with higher usage in Finland and Sweden.

Precocious puberty is starting earlier due to factors like obesity and chemicals, with treatment focusing on preserving height and addressing social issues.

Obesity leads to physical, metabolic, reproductive issues, higher healthcare costs, and mental health problems.

Finasteride may decrease semen quality but not harm sperm production, and stopping the drug can improve semen quality; hyperprolactinemia can cause infertility but is treatable with medication.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Using anabolic androgenic steroids can cause serious, lasting health problems in many parts of the body.

Polycystic ovary syndrome (PCOS) was first described in 1721, officially diagnosed in the 1990s, and is now known to be partly genetic and linked to insulin resistance, with increased risk of cardiovascular disease and carbohydrate metabolism issues.

Delayed ejaculation is a complex issue caused by psychological, biological, and lifestyle factors, requiring a holistic treatment approach.

The X5 Hairlaser might help treat male hair loss, but more research is needed.

New treatments for excessive hair growth in women include insulin modulators and enzyme inhibitors.

5α-reductase inhibitors may worsen sexual drive and spontaneous erections but don't worsen existing erectile or ejaculatory problems.

Nandrolone might increase muscle mass with fewer side effects than testosterone but could cause erectile dysfunction and needs more research.

Foxp3+ Regulatory T Cells are important for immunity and tolerance, affect hair growth and wound healing, and their dysfunction can contribute to obesity-related diseases and other health issues.

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

Zinc is essential for many body functions and imbalances can lead to health problems.