Disruptors of Androgen Action and Synthesis

January 2015 in “ Elsevier eBooks ”

J. Thomas Sanderson

antiandrogenic effects testosterone dihydrotestosterone DHT androgen receptor AR steroidogenic enzymes cytochrome P450 17 steroid 5α-reductase p,p-DDE vinclozolin antiandrogens steroid enzymes cytochrome P450 5α-reductase DDE

TLDR Certain pesticides and fungicides can interfere with male hormone functions, potentially causing reproductive issues in male rats.

Various environmental chemicals were found to exert antiandrogenic effects in animals, raising concerns about potential adverse effects in humans. These chemicals could disrupt androgen functions by competing with testosterone and dihydrotestosterone (DHT) for the androgen receptor (AR) or by inhibiting key steroidogenic enzymes like cytochrome P450 17 and steroid 5α-reductase. Notable chemicals include pesticides like p,p-DDE and fungicides like vinclozolin, which caused reproductive malformations in male rats. While many compounds acted as estrogens, few acted as androgen mimics. The human health impact of environmental antiandrogens remained unclear.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations, May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride

research A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride

60 citations, December 1998 in “Clinical Pharmacology & Therapeutics”

Both drugs lower DHT levels, with GI198745 being more effective.

Related Community Posts Join

6 / 368 results

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 1 upvotes 2 weeks ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 411 upvotes 2 weeks ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

in Research/Science 129 upvotes 1 year ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

community 18 months. Dutasteride, RU58841, Minoxidil, Microneedling, Nizoral, T/GEL

in Progress Pictures 168 upvotes 4 years ago

A 28 year old man's 18-month journey to treat his hair loss with Dutasteride, RU58841, Minoxidil, Microneedling, Nizoral and T/GEL. He experienced some side effects along the way, including translucent semen and scalp less oily.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 47 upvotes 7 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

in Progress Pictures 224 upvotes 8 months ago

A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

Similar Research

6 / 1000+ results

research Hormonal Treatment for Skin Androgen-Related Disorders

January 2015

Hormonal treatments can help with hair loss, acne, and excess hair growth, but it takes 3-6 months to see results and patients should know the possible side effects.

research Pharmacological Options for Treatment of Hyperandrogenic Disorders

6 citations, August 2009 in “Mini-reviews in Medicinal Chemistry”

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

research Antiandrogens and Androgen Inhibitors in Dermatologic Treatments

November 2020 in “Elsevier eBooks”

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

research Androgen Receptor Antagonists Structure-Activity Relationships

204 citations, February 2000 in “Current Medicinal Chemistry”

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

research Acne

81 citations, January 2002 in “American journal of clinical dermatology”

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

research Antiandrogen Therapy in Dermatology

32 citations, November 1996 in “International Journal of Dermatology”

Antiandrogens can help treat skin conditions like acne and excessive hair in women when used carefully.