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Did you mean Cytochrome P450 17A1?

GlossaryCYP17A1 (Cytochrome P450 17A1)

enzyme crucial for steroid hormone production

CYP17A1, also known as Cytochrome P450 17A1, is an enzyme that plays a crucial role in the production of steroid hormones. It is involved in the conversion of pregnenolone and progesterone into their 17-alpha-hydroxylated products, which are precursors for androgens and estrogens. This enzyme is essential for the synthesis of hormones that regulate various bodily functions, including metabolism, immune response, and sexual development.

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11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro

research 11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro

7 citations, April 2019 in “The Journal of Steroid Biochemistry and Molecular Biology”

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

research Disruptors of Androgen Action and Synthesis

1 citations, January 2015 in “Elsevier eBooks”

Certain pesticides and fungicides can interfere with male hormone functions, potentially causing reproductive issues in male rats.

research Hyperandrogenism in Polycystic Ovarian Syndrome and Role of CYP Gene Variants: A Review

49 citations, November 2019 in “Egyptian Journal of Medical Human Genetics”

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

research Steroidal 5α-Reductase and 17α-Hydroxylase/17,20-Lyase (CYP17) Inhibitors Useful in the Treatment of Prostatic Diseases

51 citations, May 2013 in “The Journal of Steroid Biochemistry and Molecular Biology”

Certain drugs that block specific enzymes can help treat prostate diseases.

17-Hydroxyprogesterone Responses to Gonadotropin-Releasing Hormone Reveal Distinct Phenotypes of Functional Ovarian Hyperandrogenism and Polycystic Ovary Syndrome

research 17-Hydroxyprogesterone Responses to Gonadotropin-Releasing Hormone Reveal Distinct Phenotypes of Functional Ovarian Hyperandrogenism and Polycystic Ovary Syndrome

42 citations, September 2007 in “The Journal of Clinical Endocrinology and Metabolism”

The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.

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community How to BECOME a RESPONDER to Fin/Dut if you are not responding

in Finasteride/Dutasteride 308 upvotes 1 year ago

The conclusion of this conversation is that the user "DuckSeasonCamelSeasn" found that consuming grapefruit juice prior to taking finasteride or dutasteride helped them become a responder to the medications and regain hair growth. However, there are warnings about potential risks and interactions with other medications, so caution should be exercised.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community How does finasteride leave your body?

in Chat 13 upvotes 6 months ago

Finasteride is metabolized in the liver and excreted through urine and feces. Users humorously discuss its excretion, with one joking about it being expelled through ejaculation.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Should I apply my grapefruit topically instead of injecting it into my bloodstream?

in Satire 74 upvotes 1 year ago

The conversation is a satirical discussion about using grapefruit for hair regrowth, with suggestions ranging from injecting it to applying it topically or anally. Some users claim unusual benefits like emitting a green aura or jumping high.

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