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    Glossary Prolactin Receptor

    protein on cell surfaces that binds to prolactin hormone

    The Prolactin Receptor (PRLR) is a protein found on the surface of certain cells that binds to the hormone prolactin. This interaction is crucial for various biological processes, including lactation, reproductive functions, and immune system regulation. In the context of hair biology, prolactin and its receptor can influence hair growth and hair cycle regulation.

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    1. Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen American Journal of Pathology · 2003 · 91 citations
    2. Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice* Endocrinology · 2001 · 73 citations
    3. The prolactin receptor as a therapeutic target in human diseases: browsing new potential indications Expert Opinion on Therapeutic Targets · 2015 · 38 citations
    4. Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles <i>in vitro</i> British Journal of Dermatology · 2010 · 37 citations
    5. A Neutralizing Prolactin Receptor Antibody Whose In Vivo Application Mimics the Phenotype of Female Prolactin Receptor-Deficient Mice Endocrinology · 2015 · 14 citations
    6. Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice Endocrinology · 2001 · 14 citations
    7. Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women Reproductive Sciences · 2018 · 3 citations
    8. Canonical prolactin signaling and global mRNA expression in the skin of Holstein heifers carrying the SLICK1 allele of the prolactin receptor gene Journal of Dairy Science · 2025 · 1 citations
    9. 1049 Novel strategy to promote hair follicle growth and stem cell activation in human male scalp skin: Targeting prolactin receptor with ABS-201 Journal of Investigative Dermatology · 2026
    10. Determining the Relationship Among Cattle Genotype, Hair Coat Score, and Productivity Through the Investigation of Single Nucleotide Polymorphisms within Prolactin, Dopamine Receptor D2, and Melatonin Receptor 1A 2019
    11. Prolactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone Journal of Investigative Dermatology · 2008 · 98 citations
    12. Prolactin delays hair regrowth in mice Journal of Endocrinology · 2006 · 53 citations
    13. Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin PLOS ONE · 2013 · 24 citations
    14. Utilizing the hair follicle to dissect the regulation and autocrine/paracrine activities of prolactin in humans 2012 · 12 citations
    15. Impact of mutations in PRLR for hair weight, circulating prolactin concentrations, feed intake, and growth of beef cattle in a hot and humid climate Frontiers in Endocrinology · 2026
    16. Prolactin—a novel neuroendocrine regulator of human keratin expression<i>in situ</i> The FASEB Journal · 2010 · 64 citations
    17. Role of estrogen receptor signaling in the control of the hair follicle cycle 2004
    18. Inhibition of prolactin promotes secondary skin follicle activation in cashmere goats 2021 · 7 citations
    19. Hormonal Effects on Hair Follicles International journal of molecular sciences · 2020 · 102 citations
    20. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation Genes & Development · 2014 · 40 citations
    21. Harnessing neuroendocrine controls of keratin expression: A new therapeutic strategy for skin diseases? BioEssays · 2014 · 26 citations
    22. Finasteride and male fertility Journal of Human Reproductive Sciences · 2011 · 1 citations
    23. Recent approaches of antibody therapeutics in androgenetic alopecia Frontiers in Pharmacology · 2024
    24. Effects of the bovine slick mutation on heat stress responses and hair growth in mice 2020
    25. Emerging pharmacotherapies for Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2026
    26. Neuroendocrine Controls of Keratin Expression in Human Skin IntechOpen eBooks · 2018
    27. Effects of short photoperiod on cashmere growth, hormone concentrations and hair follicle development-related gene expression in cashmere goats Journal of applied animal research · 2023
    28. Hair and Scalp Variation Related to Gender Springer eBooks · 2018
    29. Endocrine control of benign prostatic hyperplasia Andrology · 2016 · 97 citations
    30. Molecular Genetic and Endocrine Mechanisms of Hair Growth Hormone Research in Paediatrics · 2003 · 51 citations