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The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

People with polycystic ovary syndrome may have a higher risk of heart problems due to abnormal nervous system control of their heart and blood pressure.

Ketoconazole reduced hair growth and improved acne in women, but caused side effects needing careful monitoring.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

Taking DHEA for a year is generally safe for postmenopausal women but may cause acne and more facial hair without improving metabolism or aging.

To diagnose Polycystic Ovarian Syndrome, two out of three signs—irregular periods, high male hormone levels, or cysts on the ovaries—are needed.

Women with PCOS are more likely to have fatty liver disease, especially if they have metabolic problems.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Menopause significantly reduces skin collagen, leading to thinner, less elastic skin, and hormone replacement may help but requires careful consideration.

Women with PCOS are more likely to have insulin resistance and obesity, especially those with the most severe type I PCOS.

The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.

The document concludes that correct diagnosis and management of PCOS are important, and more research is needed on its risks and treatments.

Excessive hair growth can be assessed by history, exam, and blood tests, and treated with medication like dexamethasone, birth control pills, and spironolactone.

The conclusion is that oral contraceptives and antiandrogens can treat hirsutism and acne in women with cutaneous hyperandrogenism, but more research is needed for effective treatments, especially for hair loss.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Nanoparticles with more oleic acid improved the delivery and stability of the drug spironolactone.

Hirsutism is excessive male-pattern hair growth in women, often caused by hormonal imbalances, and requires ongoing treatment to manage.

Hair problems are common and distressing for women, but increasing knowledge of treatments offers hope.

Shorter CAG repeats in a specific gene may increase male hormone activity and symptoms like acne and excess hair in women with PCOS.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Barley extract, specifically procyanidin B-3, can promote hair growth and counteract growth inhibition.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Minoxidil effectively treats female pattern hair loss.

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

Many young Italian women have hyperandrogenic disorders like PCOS, which are linked to age, body weight, and insulin resistance.