26 citations
,
October 2017 in “Clinical Reviews in Allergy & Immunology” This review explores skin manifestations associated with autoimmune liver diseases and highlights known and probable links, such as vitiligo's strong association with autoimmune hepatitis.
2 citations
,
September 2016 in “Symbiosis online journal of veterinary sciences” This report details a case of feline degenerative mucinotic mural folliculitis associated with feline immunodeficiency virus, identified using immunohistochemistry and immunoassay techniques.
1 citations
,
June 2012 in “Actas Dermo-Sifiliográficas” This article discusses primary cicatricial alopecia, highlighting the need for early and precise diagnosis to effectively manage and treat these complex inflammatory hair disorders, but presents no new clinical results.
February 2026 in “World Academy of Sciences Journal” This case report describes a rare occurrence of primary cutaneous diffuse large B-cell lymphoma, not otherwise specified (PCDLBCL-NOS) on the scalp of a 45-year-old female, highlighting its unusual presentation and the initial treatment response but also noting severe subsequent complications.
This review analyzed literature on primary cutaneous lymphomas involving the scalp, finding that scalp involvement in these cases often leads to non-scarring focal alopecia and may indicate more aggressive disease.
118 citations
,
August 2010 in “Developmental Cell” This study found that the protein MIM is crucial for maintaining cilia and Sonic hedgehog signaling in mesenchymal cells by counteracting Src-mediated phosphorylation of Cortactin, impacting hair follicle formation.
101 citations
,
December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports the successful differentiation of mouse induced pluripotent stem cells into keratinocytes that can regenerate skin and its structures in an in vivo environment.
6 citations
,
February 2013 in “Journal of Visualized Experiments” This study introduces a method using lentiviral delivery in mice to expedite analysis of factors crucial for hair follicle morphogenesis by enabling rapid gain- or loss-of-function studies.
3 citations
,
August 2022 in “International Journal of Molecular Sciences” This study demonstrated that 5-azacytidine treatment may reduce TSC lesion-related hair follicles in mice, suggesting chromatin remodeling agents could be effective for tuberous sclerosis cutaneous lesions lacking tuberin.
2 citations
,
August 2022 in “BMC veterinary research” This study confirmed the biological characteristics and multipotent differentiation potential of primary and secondary hair follicle stem cells from Arbas Cashmere goats, contributing to the understanding of adult stem cell types and characteristics.
30 citations
,
January 2021 in “Journal of Clinical Immunology” This study describes various clinical phenotypes associated with FOXN1 mutations, finding that affected individuals may develop different severities of immunodeficiency based on their genetic mutations.
17 citations
,
June 2017 in “Gene” This is the first report of the FOXN1 p.R255X mutation from India, demonstrating the global spread of this genetic mutation previously found only in an Italian community.
May 1991 in “Current problems in dermatology” This article reviews the relationship between the skin and the immune system and discusses how skin manifestations can indicate immunodeficiencies but reports no new research findings.
33 citations
,
September 2017 in “Journal of clinical immunology” This review summarizes recent findings on FOXN1's essential role in thymus and skin biology and discusses emerging therapeutic approaches for immune disorders with athymia, but reports no new clinical results.
184 citations
,
December 2018 in “Nature Communications” This study demonstrated that enhancing human skin constructs with hair follicles through engineered cell organization and vascularization improved hair growth in immunodeficient mice, suggesting potential advances for treating alopecia and chronic wounds.
5 citations
,
July 2018 in “Experimental Dermatology” In this study, researchers developed a relatively simple punch assay for regenerating hair follicles using mouse or human cells, finding efficient hair formation with mouse cells but low efficiency with human cells on reconstituted human skin.
4 citations
,
October 2021 in “Journal of family medicine and primary care” This study found that 66.3% of primary healthcare center attendees in the Jazan region reported experiencing hair loss, with the majority being female and most commonly identifying telogen effluvium.
January 2019 in “Annals of Dermatology” This study observed that in Korean HIV patients, tinea infection, folliculitis, and seborrheic dermatitis were the most common skin diseases, with HAART medications generally reducing folliculitis incidence. Skin disease prevalence differed by immune status, affecting treatment needs.
17 citations
,
October 2021 in “Cellular & Molecular Biology Letters” This study identified novel biomarkers through gene expression differences between keratinocytes and fibroblasts in newborn mice, which may aid in developing therapies for skin conditions.
1 citations
,
September 2022 in “F1000Research” This case report describes a 56-year-old man with late-onset systemic lupus erythematosus where digital gangrene was an initial manifestation, highlighting its rarity as a primary sign.
August 2022 in “F1000Research” This case report describes digital gangrene as a rare primary manifestation of late-onset systemic lupus erythematosus in a 56-year-old man, with marked lesion improvement following rituximab treatment.
2 citations
,
January 2019 in “Methods in molecular biology” This protocol demonstrates that pharmacological inhibition of TGF-β signaling can enhance the proliferative capacity of mouse and human keratinocytes, facilitating their use in skin research and graft preparation.
January 2024 in “Faculty of 1000 Research Ltd” This report describes a case of digital gangrene as an early manifestation of systemic lupus erythematosus in a 56-year-old man, highlighting it as a rare complication of late-onset SLE.
January 2022 in “Faculty of 1000 Research Ltd” This case report documents digital gangrene as an unusual early sign of late-onset systemic lupus erythematosus in a 56-year-old man, which improved with rituximab treatment.
45 citations
,
April 2019 in “International Immunology” This review discusses the mechanisms behind alopecia areata and primary cicatricial alopecia and reports no new clinical results, aiming to guide the development of targeted treatments.
2 citations
,
August 2025 in “Harm Reduction Journal” This study highlights the severe health risks and dependence associated with non-medical androgen use among gym-goers, stressing the need for specialized primary care and harm-reduction strategies due to potentially fatal outcomes even after prolonged cessation.
February 2026 in “BMC Genomics” This study found that MEG3-miRNAs are key regulators of the age-dependent crimped wool trait in Tan sheep, likely influencing primary follicle development and degeneration through immune-inflammatory pathways.
64 citations
,
January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that ectodermal precursor cells derived from human induced pluripotent stem cells may enhance hair follicle morphogenesis through improved epithelial-mesenchymal interactions when cocultured with dermal cells.
23 citations
,
July 2020 in “Aging Cell” In this study, researchers found that glycan profiles in epidermal stem cells differed between young and old mice, suggesting these changes may serve as molecular markers for aging.
241 citations
,
August 2005 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses the roles of sebaceous gland activity, Malassezia yeast, and individual susceptibility in scalp flaking disorders, including dandruff and seborrheic dermatitis, but reports no new experiment results.