Primary Cutaneous Diffuse Large B-Cell Lymphoma of the Scalp: A Case Report and Brief Review of the Literature

    February 2026 in “ World Academy of Sciences Journal ”
    Ronak Ahmed, Dana O. Karim, Sami S. Omar, Sharaza Homar, Rawa Ali, Hawkar A. Nasralla, Kayhan A. Najar, Shvan Omar Siddiq, Sarhang Sedeeq Abdalla, Fahmi H. Kakamad
    TLDR Lymphoma should be considered in unusual scalp hair loss cases, as treatment can work but may lead to severe complications.
    This case report details a rare instance of primary cutaneous diffuse large B-cell lymphoma, not otherwise specified (PCDLBCL-NOS), on the scalp of a 45-year-old female, presenting with atypical alopecic lesions. The patient experienced localized hair loss with mild erythema and pruritus, and was diagnosed with stage IA(E) PCDLBCL-NOS after a biopsy and imaging. Treated with six cycles of R-CHOP chemotherapy, she initially achieved remission but later developed B-cell acute lymphoblastic leukemia and succumbed to complications from severe neutropenic sepsis. This case emphasizes the need to consider lymphoma in atypical alopecic scalp lesions and highlights both the potential for treatment response and the risk of severe complications. Only five other cases of scalp PCDLBCL have been reported, all in males.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 490 results

      community Scientific evidence for Peppermint & Rosemary oils + My Experience

      in Research/Science  114 upvotes 3 years ago
      Natural treatments for hair loss, specifically peppermint oil and rosemary oil; how they can be used as a supplementary or alternative treatment to pharmaceuticals such as finasteride and minoxidil; and the personal experience of the user Divallo, who has seen an increase in density and thickness after using these oils for around 2.5 years. The post also touches on the potential antifungal properties of the oils and their effects on cutaneous blood flow.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 6 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community A Different Take on Curing MBP

       15 upvotes 7 years ago
      Addressing hair loss by focusing on posture, blood flow, and craniofacial development. Methods include improving posture, cardiovascular activity, scalp massages, healthy diet, meditation, using minoxidil, and addressing craniofacial issues.

      community I love Costco. Fin is less than $3 per month without insurance.

      in Finasteride/Dutasteride  128 upvotes 2 years ago
      The conversation discusses the affordability of finasteride for hair loss treatment, with users sharing that it can be obtained for less than $3 per month at Costco without insurance, and the cost can be further reduced by getting a year's prescription at once. Some users also mention getting prescriptions from their primary care physician or online services.

    Similar Research

    5 / 1000+ results