14 citations
,
July 1994 in “Journal of Dermatological Science” In this study, transgenic mice expressing a mutant K6 gene developed progressive scarring alopecia and keratosis, suggesting they may model a new keratin disorder.
1 citations
,
January 2014 in “PubMed” This study found that PK11195 treatment weakened exploratory behavior in two strains of mice, while finasteride and indomethacin decreased exploration in laboratory rodents regardless of species.
January 2014 in “프로그램북(구 초록집)” This study found that platelet-rich plasma injections followed by mesotherapy improved hair count and thickness in alopecia patients, with no significant side effects reported.
3 citations
,
June 2022 in “European journal of human genetics” This study reports the first cases of recessive KRT17-related pachyonychia congenita involving all ectodermal derivatives in seven members of two consanguineous Pakistani families.
May 2024 in “Dermatologic surgery” In this study involving 15 women with alopecia, subcutaneous scalp injections of platelet-rich plasma every four weeks for three sessions led to increased hair and hair follicle density at 24 weeks, with common side effects being local swelling and pain.
14 citations
,
June 2001 in “Endocrinology” This study found that disrupting the PRL gene in mice alters the timing of hair cycling events, causing earlier molts and changes in hair characteristics, particularly affecting female mice more significantly.
January 2024 in “Wiadomości Lekarskie” This article reviews the potential applications of Point of Care procedures in radiology, discussing their ability to enhance the speed of diagnosis and treatment but does not report new results.
26 citations
,
February 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that cutaneous pyridoxal 5'-phosphate hydrolase activity may be carried out by an enzyme different from the classical tissue-nonspecific alkaline phosphatase in human and mouse skin.
31 citations
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August 2005 in “The American Journal of Dermatopathology” This study investigated the histopathology of ectodermal dysplasia/skin fragility syndrome, identifying specific skin and hair abnormalities associated with PKP1 gene mutations in two young female patients.
22 citations
,
October 2018 in “Molecular Medicine Reports” In this study, classic PDRN (50-1,500 kDa) was observed to improve wound healing quality in a mouse model by enhancing collagen composition and cell migration.
4 citations
,
April 2022 in “Microorganisms” In this study, clinically used preoperative skin preparations with povidone iodine and chlorhexidine gluconate did not meet FDA log-reduction standards for bacterial bioburden in a porcine model, suggesting persistent infection risks.
12 citations
,
June 2020 in “Journal of The American Academy of Dermatology” This article discusses platelet-rich plasma therapy for cicatricial alopecias like lichen planopilaris and reports no confirmed new clinical results; the authors highlight ongoing uncertainty about its effectiveness and potential risks.
5 citations
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October 2024 in “International Journal of Molecular Sciences” This study observed that piperonylic acid activated key signaling pathways in dermal papilla cells and increased hair growth markers, and a clinical trial showed users of a piperonylic acid formulation had more hair than those using a placebo, suggesting its potential for treating hair loss.
In this observational and interventional study conducted in Dhaka, Bangladesh, PRP treatment led to clinical improvements in hair count, thickness, and density among 20 out of 30 male patients with androgenetic alopecia, with significant statistical support (p-value 0.00) following 2-3 treatment sessions.
The project developed and tested a method using plasma rich platelets to treat hair loss.
March 2024 in “Journal of cosmetic dermatology” This study found that platelet-rich plasma may be more effective and satisfactory than topical clobetasol for treating lichen planopilaris over six months.
1 citations
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November 1987 in “Journal of The American Academy of Dermatology” Isotretinoin can raise CPK levels, so patients need monitoring, especially before surgery.
60 citations
,
May 2015 in “Archives of dermatological research” This review discusses the role of peroxisome proliferator-activated receptors and their agonists in dermatology but reports no new clinical results.
49 citations
,
July 2000 in “Journal of Histochemistry & Cytochemistry” This study found cell-specific variations in POMC mRNA and peptide expression in murine skin, suggesting that PC1 and PC2 convertases contribute to differential POMC processing.
5 citations
,
September 2024 in “Biomolecules and Biomedicine” This study found that total glucosides of paeony (TGP) reduced hair loss and inflammation in alopecia areata mice by inhibiting cellular pyroptosis.
October 2025 in “Frontiers in Toxicology” This study found that a human relevant potency threshold for estrogen receptor alpha agonism may serve as a health-protective screening tool, and highlights inference performance as essential for scientific confidence frameworks.
26 citations
,
January 1992 in “Carcinogenesis” This study suggests that chronic treatment with TPA in mouse skin selectively expands a keratinocyte subpopulation hyperinducible for ODC, which may be a key target for neoplastic transformation.
November 2023 in “Manuju” This paper discusses the complex relationship between polycystic ovary syndrome (PCOS) and hyperprolactinemia, noting a decrease in prolactin levels following bromocriptine treatment, but reports no new clinical findings.
16 citations
,
June 2015 in “Pediatric dermatology” This review discusses lichen planopilaris in children and highlights its rarity, potential for misdiagnosis, and need for suspicion in atypical or treatment-resistant alopecia cases, but reports no new results.
January 2023 in “Journal of orthopedics & bone disorders” This study suggests that platelet-rich plasma's high levels of growth factors may be limited in promoting bone regeneration due to the concurrent release of Dickkopf-1, which inhibits osteogenesis.
3 citations
,
April 2021 in “PLoS ONE” The authors concluded that controlling voltage, pulse width, and calcium concentration in pulse electric field-activated platelet-rich plasma enhances the release of growth factors and serotonin without causing clot formation, suggesting potential clinical advantages over bovine thrombin-activated PRP.
98 citations
,
December 2008 in “Journal of Investigative Dermatology” This review discusses the possible impacts of prolactin on skin conditions like psoriasis, alopecia, and stress-related dermatoses, emphasizing the need for further research to explore its therapeutic potential.
10 citations
,
December 2008 in “Molecular Carcinogenesis” This study found that overexpressing the PML protein in transgenic mice decreased skin tumor occurrence and delayed their progression, highlighting PML's potential role in influencing keratinocyte growth and differentiation.
2 citations
,
May 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, hydrophilic EG7 PTK-UR foams promoted better wound healing and tissue integration in a porcine model compared to more hydrophobic PTK-UR variants and a polyester-based alternative, while matching a collagen-based standard.
July 2018 in “Hair transplant forum international” This study observed significant variation in platelet concentrations across four different platelet-rich plasma (PRP) systems, suggesting that PRP system choice may affect treatment outcomes for hair growth.