ROS-Degradable Polythioketal Urethane Foam Dressings to Promote Porcine Skin Wound Repair

    May 2021 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Prarthana Patil, Katherine A. Russo, Joshua McCune, Alonda C. Pollins, Matthew A. Cottam, Bryan R. Dollinger, Juan M. Colazo, Fang Yu, John R. Martin, Mukesh Kumar Gupta, Nancy L. Cardwell, Jeffrey M. Davidson, Callie M Thompson, Adrian Barbul, Alyssa M. Hasty, Scott A. Guelcher, Craig L. Duvall
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    TLDR A special foam called EG7 PTK-UR helps heal skin wounds better than other similar materials, working as well as a top-rated product and better than a polyester foam.
    The study explored the use of ROS-degradable polythioketal (PTK) urethane (UR) foams as synthetic biomaterials for wound healing. The most hydrophilic PTK-UR variant, with 7 ethylene glycol (EG7) repeats flanking each side of each thioketal bond, showed the highest ROS reactivity. In a porcine skin wound healing model, this EG7 PTK-UR foam promoted tissue integration, ECM deposition, and re-epithelialization of full-thickness skin wounds more effectively than more hydrophobic PTK-UR variants. It also resulted in resolution of type 1 inflammation and lower foreign body response. The EG7 PTK-UR foams performed similarly to a collagen-based clinical gold standard product, Integra Bilayer Wound Matrix (BWM), and outperformed polyester UR foam-based NovoSorb Biodegradable Temporizing Matrix (BTM) in terms of increased ECM production, vascularization, and biomaterial-associated immune phenotype. The study concludes that PTK-UR foams warrant further development as a new class of synthetic biomaterial foams for skin wound healing applications.
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