research Rare Case of Ovarian Steroid Cell Tumor Not Otherwise Specified in a Postmenopausal Woman
A woman's rare ovarian tumor was treated with surgery, which stopped her symptoms and normalized her hormone levels.
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research Diabetogenic Potential of Dexamethasone and Effect of Annona Muricata Methanolic Bark Extract as Post-Exposure Therapy in Albino Rats
Dexamethasone can cause diabetes in rats, and Annona muricata bark extract may help lower blood sugar.
research Parity-Related Variation in Cortisol Concentrations in Hair During Pregnancy and Postpartum: A Prospective Cohort Study
First-time mothers had higher stress hormone levels in late pregnancy than mothers who had given birth before.
research Transurethral Resection Urinary Retention Predictor (TURP) Score: A Novel Perioperative Predictor of Post-Operative Urinary Retention
A new score can help predict which patients might have trouble urinating after prostate surgery.
research Unravelling a Novel Role for Cannabidivarin in the Modulation of Subventricular Zone Postnatal Neurogenesis
Cannabidivarin (CBDV) helps new brain cells grow and develop in a specific brain area through a certain receptor.
research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Post-Finasteride Syndrome
research Overexpression of Spermidine/Spermine N1-Acetyltransferase Under the Control of Mouse Metallothionein I Promoter in Transgenic Mice: Evidence for a Striking Post-Transcriptional Regulation of Transgene Expression by a Polyamine Analogue
The study involved generating a transgenic mouse line overexpressing the SSAT gene under a mouse metallothionein I promoter, leading to significant changes in tissue polyamine pools and delayed permanent hair loss compared to previous models. The liver was notably affected, with altered polyamine levels. Despite high SSAT mRNA levels, enzyme activity was only moderately increased unless induced by ZnSO4 or the polyamine analogue DENSPM, which caused a dramatic increase in enzyme activity and depletion of liver polyamines, resulting in high mortality and liver damage. The findings suggested that SSAT overexpression made the mice highly sensitive to polyamine analogues, indicating a post-transcriptional regulation mechanism.
research Tinea Capitis Mimicking Dissecting Cellulitis of the Scalp: A Histopathologic Pitfall When Evaluating Alopecia in the Post-Pubertal Patient
A fungal infection can look like a different scalp condition in teens, leading to wrong treatment until proper tests are done.
research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque
Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.
research Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State
Smad1 and Smad5 are essential for hair follicle development and stem cell sleepiness.
research Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats
Treatment during development affects hormone balance and sexual behavior in male rats.
research A Systematic Review of Acute Telogen Effluvium, a Harrowing Post-COVID-19 Manifestation
COVID-19 can cause a type of hair loss that usually starts 74 days after infection, affecting mostly women, but most patients eventually recover.
research Morphogenesis and Maintenance of the 3D Thymic Medulla and Prevention of Nude Skin Phenotype Require FoxN1 in Pre- and Post-Natal K14 Epithelium
FoxN1 gene is essential for proper thymus structure and preventing hair loss.
research Morphometric-Stereological and Functional Epididymal Alterations and a Decrease in Fertility in Rats Treated with Finasteride and After a 30-Day Post-Treatment Recovery Period
Finasteride causes lasting fertility decrease in rats.
research Overexpression of Spermidine/Spermine N1-Acetyltransferase Under the Control of Mouse Metallothionein I Promoter in Transgenic Mice: Evidence for a Striking Post-Transcriptional Regulation of Transgene Expression by a Polyamine Analogue
The study involved generating a transgenic mouse line overexpressing the SSAT gene under a mouse metallothionein I promoter, leading to significant changes in tissue polyamine pools and delayed permanent hair loss compared to previous models. The liver was notably affected, with drastic reductions in spermine and increases in putrescine. Despite high levels of SSAT mRNA, enzyme activity was only moderately elevated unless induced by ZnSO4 or the polyamine analogue DENSPM, which caused a massive increase in enzyme activity and depletion of spermidine and spermine pools. This treatment led to high mortality and liver damage, indicating that SSAT overexpression made the mice highly sensitive to polyamine analogues, suggesting a post-transcriptional regulation mechanism.
research Effect of Bariatric Surgery on Weight Loss, Nutritional Deficiencies, Postoperative Complications, and Adherence to Dietary and Lifestyle Recommendations: A Retrospective Cohort Study from Bahrain
Bariatric surgery helps with weight loss but can cause complications and nutritional deficiencies.
research Molecular Evolution of HR, a Gene That Regulates the Postnatal Cycle of the Hair Follicle
Changes in the HR gene have influenced hair growth and may lead to hair loss conditions in humans.
research SARS-CoV-2-Induced Host Metabolic Reprogramming: Nutritional Interventions for Global Management of COVID-19 and Post-Acute Sequelae
Eating plant-based anti-inflammatories and antioxidants may help manage long-term COVID-19 health issues.
research Persistent Alopecia in a Breast Cancer Patient Following Taxane Chemotherapy and Adjuvant Endocrine Therapy: Case Report and Review of Post-treatment Hair Loss in Oncology Patients with Breast Cancer
A breast cancer patient had lasting hair loss after chemotherapy, which improved with minoxidil treatment.
research A Sensitive Assay for the Enzyme Activity in Hair Follicles and Epidermis That Catalyzes the Peptidyl-Arginine-Citrulline Post-Translational Modification
A more sensitive assay was developed to detect enzyme activity converting arginine to citrulline in hair follicles.
research Platelet-Rich Plasma with Low Dose Oral Minoxidil (1.25 mg Versus 2.5 mg) Along with Trichoscopic Pre- and Post-Treatment Evaluation
Combining platelet-rich plasma therapy with low dose oral minoxidil improved hair growth in men with hair loss, with slightly higher satisfaction at the higher minoxidil dose.
research Recommendations on Non-Pharmacological Interventions in Women with PCOS to Reduce Body Weight and Improve Metabolic Disorders
Healthy diet and exercise are important for women with PCOS to manage weight and metabolic issues, and supplements like omega-3, vitamin D, and inositol may help.
research The Role of 5-Alpha-Reductase Inhibition in Suppressing Progression of Male Androgenetic Alopecia and the Potential Application of Saw Palmetto Extracts
Saw palmetto extracts might help treat male hair loss and need more research.
research The Plastic and Functional Changes in Hippocampal Neurons During Pregnancy, Delivery, and Postpartum Are Reversed by Offspring Deprivation
Pregnancy and nursing increase certain brain activities in rats, but these changes disappear when the babies are taken away.
research Photographic Evaluation of Treatment Response to Finasteride: Pre-Treatment and Post-Treatment
research A Systematic Review of Clinical Trials Using Single or Combination Therapy of Oral or Topical Finasteride for Women in Reproductive Age and Postmenopausal Women with Hormonal and Nonhormonal Androgenetic Alopecia
Oral and topical finasteride are effective and safe for treating female hair loss.
research The Diagnosis of Nonclassic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Based on Serum Basal or Post-ACTH Stimulation 17-Hydroxyprogesterone Can Lead to False-Positive Diagnosis
Using 17-hydroxyprogesterone levels to diagnose nonclassic congenital adrenal hyperplasia can result in many incorrect diagnoses.
research Maintenance of Optimized Hair Growth from Viable Terminal Scalp Hair Follicles at Baseline with Oral Finasteride in Male Pattern Hair Loss and First Evidence of a Drug Dependency and a Post-Finasteride Rebound Effect
Finasteride helps hair growth but stopping it causes faster hair loss.
research Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women
The drug BAY 1158061 is safe, well-tolerated, and shows potential for treating diseases related to prolactin.
research Structural Analysis of Curly and Straight Human Hair Fibers by Scanning Microbeam SAXS
Curly and straight hair differ in how their internal fibers are arranged.