Unravelling a Novel Role for Cannabidivarin in the Modulation of Subventricular Zone Postnatal Neurogenesis

    May 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Diogo M. Lourenço, Rita da Trindade Ribeiro Nobre Soares, Sónia Sá Santos, Joana M Mateus, Rui S. Rodrigues, João B. Moreira, Sandra H. Vaz, Ana M. Sebastião, Susana Solá, Sara Xapelli
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    Studysummary This study found that Cannabidivarin (CBDV) promotes neuronal survival, proliferation, and differentiation via TRPV1 activation but inhibits oligodendrocyte differentiation in postnatal neurogenesis.
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    The study investigates the role of Cannabidivarin (CBDV), a non-psychoactive cannabinoid, in postnatal neurogenesis in the subventricular zone (SVZ). Using a neurosphere assay, neural stem/progenitor cells (NSPCs) from the SVZ were treated with CBDV and/or 5’-Iodoresinferotoxin (a TRPV1 antagonist). The results showed that CBDV promotes cell survival, proliferation, and neuronal differentiation through a TRPV1-dependent mechanism. Additionally, CBDV was found to inhibit oligodendrocyte differentiation and maturation. The study also found that CBDV-responsive cells displayed a two-phase calcium influx profile, with the initial phase dependent on TRPV1 activation. These findings suggest that CBDV has a novel neurogenic potential via TRPV1 modulation, which could be valuable for future neural stem cell studies and repair strategies.
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