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This study found that Frizzled genes Fzd3 and Fzd6 are redundantly involved in controlling hair follicle polarity in mice, but operate through distinct mechanisms, highlighting their complex role in hair orientation.

This study found that disrupting the inturned gene in developing mouse epidermis halted hair follicle formation due to impaired keratinocyte differentiation, highlighting primary cilia's role in tissue-specific planar cell polarity signaling.

This study found that proton minibeam radiotherapy demonstrated a potential tissue-sparing effect in epidermis models by spatially confining DNA damage, suggesting reduced side effects in radiotherapy.

This study found that Celsr1, not Celsr2, is the primary protein involved in establishing planar cell polarity and hair follicle polarization in the epidermis of mice.

In this study, researchers explored how hair follicle orientation is affected in the rosette fancy mouse and found that a mutation in the PCP gene Fzd6 caused reversed hair orientations in the posterior region, leading to the formation of unique whorls.

Genetic defects in the Wnt/PCP pathway may cause congenital yellow nail syndrome.

This study found that plantar dermis matrix homogenate can partially restore the regenerative capacity of hair follicles impaired in culture, with CTHRC1 playing a critical role in this process.

This case report observed a dramatic improvement in a 15-year-old girl's pachyonychia congenita symptoms during chemotherapy for Ewing sarcoma, suggesting chemotherapy's potential role in managing hyperkeratotic conditions.

In this study, metabolic syndrome and hypertension were significantly more prevalent in patients with plantar callosities compared to controls, suggesting potential links that warrant further investigation.

In this study, microneedling combined with bleomycin treatment for plantar warts improved the response time and reduced the number of treatment sessions needed, with a relapse rate similar to other injection-based methods.

In this pilot study, both microneedling and CO2 laser combined with hair transplantation and nbUVB demonstrated potential for inducing repigmentation in refractory palmar-plantar vitiligo, though further research is needed to ascertain their relative efficacy.

This case report documents a rare instance of a trichilemmal cyst occurring on the plantar surface of the foot, highlighting the necessity of histological examination for accurate diagnosis when clinical or radiological presentations are atypical.

In this study, researchers presented a protocol for generating planar skin organoids from human induced pluripotent stem cells, which include hair follicles and other skin structures, offering a relevant in vitro model for investigating skin physiology, pathogen interactions, and drug responses.

This study found that mercury chloride administration in rats led to decreased intraepidermal nerve fibers and increased Langerhans cells, suggesting small nerve fiber damage after mercury poisoning.

In this study, radial shockwave therapy significantly improved muscle spasticity, ankle range of motion, and functional abilities in children with spastic cerebral palsy, suggesting it may help them achieve greater autonomy in daily activities.

This study demonstrated that Wnt5a can serve as an orienting signal for mouse skin's planar cell polarity but its overexpression disrupts hair follicle orientation, which can be rescued by modifying Fzd6 levels.

This review discusses the similarities between wound healing and embryonic development, focusing on signaling pathways and their potential for developing new wound healing strategies, and reports no new clinical results.

This study found that the proteins Par3, mInsc, and Gαi3 cooperate to regulate LGN polarization and promote perpendicular cell divisions during murine epidermal morphogenesis.

This study identified intramembrane proteolysis as a key feature of Astrotactin2 maturation, providing insights into its role in planar cell polarity hair patterning.

Obesity is linked to various skin problems and may increase the risk of skin cancer.

In this study, vemurafenib was associated with a wide range of cutaneous side effects in patients with advanced melanoma, including photosensitivity and various skin and hair changes, necessitating regular dermatological management.

This study developed an in vitro model revealing that hair follicle spheroids enhanced both sweat gland and hair follicle differentiation within bioprinted scaffolds, while microenvironmental cues supported persistent regeneration.

This study found that obesity is associated with several skin conditions, such as striae and pseudoacanthosis nigricans, which may serve as markers of excessive weight.

In this study, 13-cis-5S*,8S*-epidioxy-5,8-dihydroretinoic acid was found to be significantly more cytotoxic to cancer cell lines than other retinoic acid analogs evaluated.

This report describes two cases of chronic arsenicism, one involving criminal poisoning by a sibling and the other associated with prolonged use of Fowler's solution.

This study observed that common skin changes in patients with type 2 diabetes included peripheral hair loss, xerosis, anhydrosis, and nail alterations, underscoring the importance of controlling blood sugar and foot care to prevent neuropathy complications.

This case report details a 12-year-old boy with Lichen Spinulosus and plantar keratoderma, who responded well to topical treatments including lactic acid, urea, and betamethasone valerate.

This study found that acanthosis nigricans and skin tags in nondiabetic, obese patients were significantly associated with higher insulin levels, suggesting they may serve as clinical markers of hyperinsulinemia.

This study found that Vemurafenib led to a broad range of cutaneous side effects in nearly all patients with advanced melanoma, highlighting the need for regular dermatologic management and UV protection.