Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model

    March 2022 in “ Cancers ”
    Harry Scherthan, Stephanie-Quinta Wagner, Jan Grundhöfer, Nicole Matejka, Jéssica Müller, Steffen Müller, Sarah Rudigkeit, Matthias Sammer, Sarah Schoof, Matthias Port, Judith Reindl
    The study investigated the effects of proton minibeam radiotherapy (pMBRT) on DNA damage in a human epidermis model, using minibeams of varying widths (66 µm, 408 µm, and 920 µm) and a consistent inter-beam distance. Results showed that the 66 µm minibeams caused sharply localized severe DNA damage at dose peaks, while wider beams affected all cells. DNA damage was repaired by 72 hours post-irradiation, but increased cell death markers were observed at later time points. The findings suggested that pMBRT could minimize skin side effects in radiotherapy due to its spatially confined DNA damage, making it a promising approach for reducing radiotherapy side effects.
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