A Rare Type of Radiation-Induced Alopecia: Proton-Induced Alopecia

January 2023 in “ Skin appendage disorders ”

Davide Fattore, Vincenzo Picone, Maria Vastarella, Gabriella Fabbrocini, Maria Teresa Cantelli

proton-induced alopecia radiation-induced alopecia proton therapy trichoscopy topical minoxidil anagen phase mitotic activity hair follicles hair fragility PIA RIA PT minoxidil

TLDR A woman's hair grew back after treatment for a rare hair loss caused by proton therapy.

Proton-induced alopecia (PIA) is a rare form of radiation-induced alopecia (RIA) that occurs following proton therapy (PT) for brain tumors. This case report details a 38-year-old female who developed diffuse hair loss in the frontal region after PT for a meningioma. Trichoscopy showed typical signs of PIA, and treatment with topical minoxidil 5% resulted in complete hair regrowth within 4 months. PIA is caused by radiation damage to hair follicles in the anagen phase, leading to disrupted mitotic activity and increased hair fragility. The study emphasizes the need for more research on PIA as the use of PT grows.

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