109 citations
,
April 1997 in “Archives of Dermatological Research” The researchers reported that mast cell and nerve fiber interactions in mouse skin are highly selective for nerve fiber types and vary depending on the hair cycle phase.
2 citations
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February 2022 in “Journal of Pharmacy and Pharmacology” In this study, two methotrexate-loaded liquid crystal formulations for topical application showed immunomodulatory effects and induced skin changes in mice with imiquimod-induced psoriasis.
75 citations
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October 2002 in “Journal of Dermatological Science” This study found that Sophora flavescens extract may promote hair growth in mice by inducing earlier hair cycle changes and regulating growth factors in dermal papilla cells.
31 citations
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April 2019 in “Journal of Cutaneous Pathology” This review discusses the changes in hair follicles with aging, particularly graying due to decreased melanocyte activity, and suggests potential for hair repigmentation under certain conditions, but reports no new results.
26 citations
,
December 1999 in “Journal of Investigative Dermatology” This study found that manipulating prolactin levels in New Zealand Wiltshire sheep induces wool follicle growth cycles, revealing gene expression changes that suggest roles for specific genes in follicle function.
February 2009 in “Springer eBooks” Pregnancy can cause more body and scalp hair growth and make nails brittle, but these changes often revert after giving birth.
January 2023 in “Figshare” This review discusses changes in hair follicle characteristics and stem cell dynamics as indicators of aging in mice, noting increased occurrences of white hairs and curved hair follicles at older ages.
July 2020 in “Experimental Dermatology” This discussion of age-related changes in female scalp hair follicles reports no new results, highlighting the structural transformations that may contribute to thinning hair in women as they age.
61 citations
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April 2013 in “PloS one” This study identified numerous genes that change expression across the anagen, catagen, and telogen stages of cashmere goat hair follicle development, highlighting key signaling pathways involved.
20 citations
,
January 2015 in “Current problems in dermatology” This article discusses the aging-related changes in hair structure and function, and examines various treatments like light therapy, minoxidil, and finasteride aimed at mitigating hair thinning and loss, but reports no new clinical results.
This study found that ocu-miR-205 promotes changes in signaling pathways and shifts in hair follicle phases, affecting Rex rabbit hair density by increasing secondary follicles.
May 2025 in “Research Journal of Biotechnology” This study found that diabetic individuals experienced significant changes in hair characteristics, including reduced thickness, strength, and altered growth cycle phases, correlated with poor glycaemic control and haematological variations compared to healthy controls.
September 2023 in “Gynäkologische Endokrinologie” This review discusses how the hormonal changes of menopause affect skin and hair, highlighting improvements in skin symptoms like dryness and reduced wound healing with estrogen supplementation, and advises healthcare providers to consider broader potential benefits of menopausal hormone therapy when consulting patients.
This article reviews pathologic mechanisms causing hair changes in women on hormonal contraceptives or pregnant and reports no new study results; hormonal effects on the hair cycle stages are suggested.
127 citations
,
January 2013 in “PLOS ONE” This study found that feeding aged mice a probiotic yogurt induced changes leading to thicker, healthier fur, suggesting a bacteria-triggered interleukin-10-dependent mechanism that mimics signs of youth and reproductive fitness.
124 citations
,
August 1994 in “Journal of Investigative Dermatology” This study found that applying dexamethasone to mice induced catagen-like follicle changes significantly earlier and more consistently than a vehicle, such changes being useful for studying hair follicle regression.
98 citations
,
February 2007 in “Seminars in Cell & Developmental Biology” This review explores the hormonal regulation of hair growth and changes with season, age, and sexual development, and calls for improved treatments for hair disorders.
3 citations
,
June 2002 in “Transgenic Research” This study suggests that inducible transgenic mice showing hair follicle changes similar to telogen effluvium in humans might serve as a useful model for understanding this type of hair loss.
72 citations
,
February 2011 in “American Journal of Biological Anthropology” This study observed that eliminating positional error in hair segment analysis can improve understanding of changes in isotopic composition, aiding the identification of pathological conditions and dietary patterns.
1 citations
,
February 2024 in “Aesthetic Surgery Journal” This study found that laser hair removal results in females were not influenced by hormonal fluctuations during different menstrual cycle phases, although pain tolerance was slightly lower during menstruation without reaching statistical significance.
This study aims to describe the trichoscopic pattern of chemotherapy-induced alopecia and its changes during different phases of chemotherapy.
14 citations
,
January 2009 in “Experimental Dermatology” In this study, researchers used a rodent model to uncover key changes in how hair fibers detach, suggesting that the exogen phase should be subdivided based on club fiber status.
10 citations
,
May 2021 in “Clinical, cosmetic and investigational dermatology” In this mouse study, UVA and UVB exposure led to hair follicle miniaturization, graying, and prolonged hair cycle duration, associated with changes in stem cells and increased Wnt signaling activity.
7 citations
,
January 1981 in “Springer eBooks” The document concludes that hair biology is complex and there are still unanswered questions about hair loss and follicle changes.
1 citations
,
January 2010 This study found that ornithine decarboxylase (ODC) may play a significant role in regulating human hair growth and hair cycle changes, as inhibiting ODC reduced follicular keratinocyte proliferation and human hair growth.
March 2026 in “SKIN The Journal of Cutaneous Medicine” This study demonstrated that litifilimab significantly reduced disease activity in cutaneous lupus erythematosus by Week 16, with improvements most notable in sunlight-exposed skin areas.
This study reports that in a rat model of myocardial infarction, Zn-Cu ion sequential therapy improved cardiac function and cardiomyocyte metabolic activity by precisely regulating ion concentrations and maintaining elevated levels of the Per2 protein, important for cellular repair.
March 2009 in “Dermatology Online Journal” This study reports that blocking the epidermal growth factor receptor in cancer treatments can lead to changes in hair growth and create a "wavy" hair phenotype in some patients.
17 citations
,
August 1971 in “Journal of Investigative Dermatology” This study observed that enzyme activity influencing estradiol-to-estrone conversion in Wistar rat skin varied with the hair cycle in dorsal skin but was minimal in plantar skin.
3 citations
,
July 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study used scRNA-Seq to map the transcriptional changes during zebrafish hair cell regeneration, revealing distinct phases including injury response, transient regeneration gene activation, and reactivation of developmental programs.