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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Polymeric nanoparticles show promise for treating skin diseases.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

Allergic reactions to blood thinners are rare but can be serious, requiring careful testing and alternative treatments.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

PLD is an effective and safer alternative for treating breast cancer.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

New treatments for male hypogonadism are effective and should be personalized.

Minoxidil effectively treats severe hypertension, but watch for side effects.

The document says to treat cat fungal infections with medicine and clean the environment, noting that cats without symptoms can still spread it to humans.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Microneedle technology has improved drug delivery and patient comfort but needs more research for broader use.

Some psychiatric medications can cause hair loss, but it usually grows back after adjusting the medication.

Immunosuppressive and anti-TNF therapies in IBD patients can increase the risk of skin cancer and cause various skin issues.

Minoxidil treats high blood pressure and side effects can be managed.

Minoxidil, propranolol, and furosemide effectively control severe hypertension, but may cause sodium retention.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.