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In this study, clinically used preoperative skin preparations with povidone iodine and chlorhexidine gluconate did not meet FDA log-reduction standards for bacterial bioburden in a porcine model, suggesting persistent infection risks.

This paper introduces a framework attributing Post-SSRI, Post-Finasteride, Post-Retinoid, and an unnamed sexual dysfunction syndrome to downregulated estrogen receptor activity, potentially guiding future treatments in sexual medicine.

This study found that finasteride use is associated with both known and new adverse events, which vary by gender and age, as well as some events not previously listed in the drug insert.

This study evaluated the effect of intralesional injections of lyophilized Platelet Derived Growth Factors in 42 patients with Peyronie's disease and found significant reductions in penile curvature and plaque size, along with improvements in Peyronie's Disease Questionnaire scores, suggesting a potential treatment role.

Systematic end-of-trial biopsies are the most reliable way to assess outcomes.

This study reported that invasomes, utilizing limonene as a component, enhanced the transdermal permeation of finasteride by over 21 times, indicating their potential as a novel drug delivery system.

This paper proposes that gut dysbiosis plays a crucial role in Post-Finasteride Syndrome by possibly contributing to both androgenic and non-androgenic symptoms, and may explain fluctuating symptom cycles better than static genetic explanations.

Using finasteride with TIP extends time off period for prostate cancer patients.

This report describes two cases where pemphigus lesions developed at sites of cosmetic procedures, suggesting these treatments might trigger the disease and should be distinguished from other post-surgery complications.

In this study, researchers developed a method to control the valence states of Mo in nanozymes, optimizing their activity for ROS-related therapies, particularly acute kidney injury treatment, and enabling real-time monitoring with photoacoustic imaging.

This study found that a new analytical approach revealed an increased brain pregnenolone level following finasteride treatment in a mouse model, suggesting potential for improved understanding of neurosteroid roles in brain excitability.

This study identified significant trends in interest around selective androgen receptor modulators, with increasing attention contrasting stagnant or declining interest in post-cycle therapies and anabolic steroids, and calls for clinicians to use social and prescription data to adjust treatment protocols accordingly.

The combination of a plant extract and a peptide can increase hair pigmentation and may reverse greying.

This study identified specific genes and pathways in human Leydig cells that may contribute to Post-finasteride Syndrome, potentially informing future treatments to reverse persistent side effects.

This study introduced hydrogel microneedles loaded with palladium nanoparticles, which utilize the inherent cytotoxicity of polyethyleneimine to enhance the effectiveness of doxorubicin in treating melanoma, achieving a tumor inhibition rate of up to 98% in a murine model.

This study found that engineered extracellular vesicles (293F-EGF-EV), enriched in EGF mRNA, significantly aided skin wound healing in vitro and in a rat model by promoting fibroblast activity and improving wound recovery through processes like angiogenesis and reduced scarring.

This study demonstrated that finasteride-loaded PLGA microspheres created using a novel microfluidic device exhibit extended drug release in beagle dogs, with modifications allowing for release up to 3 months.

This study observed that N-palmitoylethanolamine (PEA) may relieve pain by enhancing de novo neurosteroid synthesis, evidenced by increased allopregnanolone levels and protein expression in pain models, dependent on PPAR-α.

In this study, ginsenoside 20(S)-protopanaxadiol-aglycone (PPD) was shown to downregulate androgen receptor expression and inhibit tumor growth in prostate cancer cells.

This case report suggests that Post-Finasteride Syndrome may involve a sustained imbalance in gut bacteria, with fermenting and hydrogen sulphide-producing bacteria disrupting hormone and mitochondrial functions.

This article evaluates clinical and scientific literature on post-finasteride syndrome, concluding that finasteride and dutasteride may cause persistent sexual, neurological, and physical adverse side effects in a subset of men.

This study found that XP-endo Finisher R was approximately twice as effective as passive ultrasonic irrigation in removing root filling material from curved mesiobuccal canals of maxillary molars.

SPET-085 effectively inhibits an enzyme linked to prostate issues, similar to finasteride.

This study analyzed pexidartinib-associated adverse events from FDA data and reported common events such as hepatic issues and systemic reactions. It highlighted sex-specific susceptibilities and reinforced the need for risk mitigation and long-term monitoring in tenosynovial giant cell tumor management.

The authors concluded that finasteride and dutasteride might have serious side effects, including persistent sexual dysfunction for some, necessitating further research and vigilant risk-benefit analysis.

This preclinical study found that exercise-induced extracellular vesicles delayed breast cancer tumor growth in mice, potentially by enhancing the immune response within the tumor microenvironment.

Finasteride's link to health issues like male breast cancer, infertility, and prostate cancer needs more research through placebo-controlled trials to confirm.

In this study, serial platelet-rich plasma injections improved voice quality and mucosal wave ratings in patients with vocal fold scar, with patient-reported outcomes showing a consistent positive trend.

This study identified PTEN as a key regulator in non-healing venous leg ulcers, suppressing immune responses and lymphangiogenesis, suggesting its potential as a therapeutic target for promoting VLU healing.