21 citations
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January 2020 in “General and Comparative Endocrinology” Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.
4 citations
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June 2023 in “Frontiers in Aging” The document explores the "middle-aging hypovascularity hypoxia hypothesis," which links age-related diseases to decreased vascularity and oxygenation during middle age. It emphasizes the role of hormonal signaling, particularly testosterone and estrogen, in reversing hypovascularity, and the impact of nitric oxide (NO) signaling on endothelial dysfunction. The hypothesis suggests that maintaining NO bioavailability through pathways like NO-cGMP could improve vasodilation and tissue oxygenation, potentially mitigating diseases such as type 2 diabetes, heart failure, and dementia. The review also discusses the testosterone–vascular–inflamm-aging triad, noting that declining testosterone levels can lead to vascular aging. It highlights the potential of PDE5 inhibitors and supplements like L-arginine and curcumin to improve vascular function. The document underscores the importance of understanding oxygen homeostasis and the role of hypoxia-inducible factor (HIF) in protecting against neurodegeneration, while also exploring translational imaging technologies to assess microcirculation changes related to aging.
1 citations
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July 2021 in “Current Issues in Molecular Biology” Father's finasteride use may affect son's fertility and testicular function.
34 citations
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July 2020 in “Frontiers in immunology” Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.
December 2023 in “Frontiers in endocrinology” Excess androgens may cause PCOS, not just be a symptom.
