18 citations
,
February 2001 in “Der Hautarzt” This case study of a 50-year-old woman with myotonic dystrophy and multiple basal cell carcinomas suggests there could be a genetic predisposition for certain cutaneous tumors in such patients.
18 citations
,
October 1984 in “International Journal of Dermatology” This article reviews the relationship between hair loss and lithium but does not provide any new clinical findings.
17 citations
,
October 2003 in “Contact dermatitis” Glycerin in hand cream can cause allergic skin reactions.
17 citations
,
May 2021 in “Journal of Cell Science” In this study, the researchers discovered that specific polyamine depletion enhances stemness in hair follicle stem cells through a mechanism independent of mRNA translation.
17 citations
,
March 2016 in “Liver international” This study found that low serum testosterone and elevated serum oestrone in men with cirrhosis are associated with worse liver disease and adverse health outcomes, suggesting oestrone as a potential ill health marker.
17 citations
,
August 2015 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study concluded that the best approach for detecting Androsta-1,4,6-triene-3,17-dione administration in horses is monitoring the metabolites M1b or M4 in urine, detectable up to 77 hours post-administration.
17 citations
,
February 2015 in “Cell Death and Disease” This study found that inhibiting AP1 transcription factor activity in the suprabasal epidermis of mice alters keratinocyte gene expression, reducing barrier integrity and mimicking human keratoderma.
17 citations
,
February 2011 in “International Journal of Cosmetic Science” This study found that individual differences between pigmented and unpigmented hair fibers in Old Order Mennonites suggest grey hair may be perceived as drier and less manageable due to small mechanical and moisture changes.
17 citations
,
December 2004 in “Bioorganic & Medicinal Chemistry Letters” This study identified N-acyl arylsulfonamides, particularly N-(Boc-piperidine-4-carbonyl)-benzenesulfonamides, as steroid sulfatase inhibitors with improved cellular potency compared to previous compounds.
17 citations
,
July 2003 in “Metabolism-clinical and Experimental” This study found that young women with female-pattern hair loss exhibit increased testosterone production rates while dihydrotestosterone production rates remain within or below the normal range.
17 citations
,
June 2001 in “Journal of the National Cancer Institute” A specific hair diffraction pattern may indicate breast cancer if tested with the correct method.
17 citations
,
March 1992 in “PubMed” This study reports that finasteride administered orally in humans is mainly metabolized through oxidative pathways, with most of the dose excreted as metabolites, primarily in the feces.
16 citations
,
July 2016 in “Veterinary Dermatology” This study found that dermoscopy can identify distinctive features in canine pattern alopecia, such as hair shaft thinning and pigmentation patterns, which may aid in diagnosing this and potentially other skin disorders.
16 citations
,
June 2022 in “Agronomy” This study found that the application of plant-derived biostimulants, Trainer® and Auxym®, significantly affected various physiological traits in lettuce, but responses varied depending on the cultivar.
16 citations
,
November 2021 in “Antioxidants” This review examines the role of oxidative stress in male hypogonadism associated with noncommunicable chronic diseases and discusses various management strategies, but it presents no new clinical findings.
16 citations
,
July 2008 in “BMC Genomics” This study shows that alpha 6 + /MHCI - cells have gene expression profiles similar to hair follicle stem cells, suggesting they may be enriched for stem cells.
16 citations
,
August 2007 in “Histopathology” This case report describes a functional adrenocortical oncocytoma that co-secreted testosterone and cortisol.
15 citations
,
July 2022 in “Biomedicines” This study found no significant difference in the severity of alopecia areata between treatments with platelet-rich plasma and triamcinolone acetonide; further high-quality trials of PRP are needed.
15 citations
,
March 2022 in “Poultry Science” In this study, in ovo injection of CHIR-99021 promoted the morphogenesis and development of feather follicles in chick embryos by activating the Wnt/β-catenin signaling pathway.
15 citations
,
April 2021 in “International Journal of Pharmaceutics” This study found that smaller mesoporous silica particles (400-600 nm) accumulated in skin furrows, suggesting their potential as carriers for enhancing the delivery of topical medications like metronidazole.
15 citations
,
January 2020 in “RSC advances” In this study, researchers developed a new Supported Ionic Liquid Phase palladium catalyst that showed effectiveness in aminocarbonylation reactions for synthesizing pharmaceutical compounds like CX-546 and a precursor of Finasteride, though results were sensitive to substrate variations and prompted palladium leaching concerns.
15 citations
,
June 2019 in “Journal of Neuroendocrinology” This study found that isoallopregnanolone reduced stress-induced tic-like behaviors and sensorimotor gating deficits in a mouse model of Tourette syndrome, suggesting potential therapeutic properties comparable to existing treatments like haloperidol and finasteride.
15 citations
,
July 2015 in “Developmental Dynamics” This study highlights the role of Orai1 in ameloblast differentiation and maturation, showing that its down-regulation affects cell proliferation and enamel formation during tooth development.
15 citations
,
July 2014 in “The journal of investigative dermatology/Journal of investigative dermatology” This article discusses the potential of induced pluripotent stem cells (iPSCs) for generating skin components, particularly for genetic skin disorder modeling and gene-corrected regenerative therapies, but reports no new clinical results.
15 citations
,
April 2014 in “Experimental Dermatology” This study observed that earlier-passage keratinocyte cultures led to superior hair follicle neogenesis in dermal-epidermal composites grafted onto immunodeficient mice, suggesting their potential utility in studying human hair follicle development.
15 citations
,
July 2013 in “Cell Reports” This study reported that Indian hedgehog (Ihh) signaling plays a crucial role in regulating tumor progression and metastasis in epithelial cancers, with Ihh deficiency leading to increased malignancy and metastasis in mice.
This chapter reviews various types of alopecia and associated skin diseases in dogs and cats but presents no new clinical findings.
15 citations
,
April 2002 in “British Journal of Dermatology” This study found no strong evidence that the human hairless gene is significantly involved in the development of androgenetic alopecia, though a minor role cannot be completely ruled out.
15 citations
,
July 1998 in “PubMed” This study found that fentanyl accumulates differently in mouse hair after systemic administration compared to external loading, suggesting ionizable functionalities of hair influence drug retention from organic solutions.
15 citations
,
June 1992 in “Veterinary Dermatology” This case report describes an 8-year-old German shepherd dog with pemphigus vulgaris whose symptoms were not adequately controlled by immunosuppressive therapy, but showed transient remission with heparin alone or combined with prednisolone.