Palladium Nanoparticles on a Pyridinium Supported Ionic Liquid Phase: A Recyclable and Low-Leaching Palladium Catalyst for Aminocarbonylation Reactions

January 2020 in “ RSC advances ”

Bernadett Adamcsik, Enikő Nagy, Béla Urbán, Péter Szabó, Péter Pekker, Rita Skoda‐Földes

TLDR The new palladium catalyst is effective and reusable for making pharmaceutical ingredients.

A new Supported Ionic Liquid Phase (SILP) palladium catalyst was developed and characterized, showing highly dispersed Pd nanoparticles (1-2 nm). It was effective in aminocarbonylation reactions, including the synthesis of pharmaceutical ingredients like CX-546, Moclobemide, Nikethamide, and a Finasteride precursor. The study highlighted the importance of fine-tuning reaction conditions for different substrates and noted that palladium loss varied with the nature of the reaction partners.

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