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Pioglitazone usually doesn't effectively treat or cure lichen planopilaris.

Activating PPAR-γ signalling can protect hair follicle stem cells from damage caused by chemotherapy.

Sebaceous glands are often preserved and PPARy expression is constant in some cases of Central Centrifugal Cicatricial Alopecia.

PPAR-γ may be a key target for treating alopecia areata and other skin conditions.

Different types of PPARγ are found in varying amounts in human skin and its parts, which could affect how skin treatments work.

PPAR alpha may help in hair growth and could be a target for treatment.

The document concludes that proper diagnosis and FDA-approved treatments for different types of hair loss exist, but treatments for severe cases often fail and future improvements may focus on hair follicle stem cells.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Fat tissue and a specific protein are crucial for healthy hair growth and maintenance.

Eating fewer calories may slow skin aging and improve skin health through various biological changes.

The document concludes that a protein involved in hair growth may link to baldness and that more research is needed on its role in hair loss and skin cancer treatments.

The conclusion suggests that focusing on certain cellular pathways may improve the prevention and repair of hair loss caused by radiotherapy.

Some maize lines resist stalk rot better due to specific genes and enzyme activities.

The cause of Frontal fibrosing alopecia, a type of hair loss, is complex, likely involving immune responses and genetics, but is not fully understood.

The research found that a protein called PPARg is important for the formation and healing of sebaceous glands, which can regenerate independently from hair follicles.

Lichen planopilaris causes permanent hair loss and scarring due to damage to hair follicles and can be mistaken for other hair loss conditions.

Cicatricial alopecia, a permanent hair loss condition, is mainly caused by damage to specific hair follicle stem cells and abnormal immune responses, with gene regulator PPAR-y and lipid metabolism disorders playing significant roles.

PPARγ is crucial for skin health but can have both beneficial and harmful effects.

Prostaglandins and the enzyme AKR1C3 could play a role in skin cancer and hair loss, and further research is needed to understand these mechanisms.

Blocking EGFR in skin cells doesn't majorly increase inflammation markers.

Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.

GMG-43AC may help reduce unwanted hair growth and treat certain hair loss conditions.

CBG may help with various medical conditions but needs more human research to confirm safety and effectiveness.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.

Substance P may worsen acne by increasing inflammation, but corticosteroids might help by reducing this effect.

New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.

Diagnose and manage CCCA with thorough history, exams, and labs; treat with anti-inflammatory agents, stress reduction, and stopping harmful hair practices.