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      The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

      research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

      144 citations , November 2020 in “Frontiers in immunology”
      This study summarizes how the IL-23/IL-17 axis contributes to inflammatory skin diseases like psoriasis and highlights that biologics targeting this pathway, including monoclonal antibodies against IL-23 and IL-17, have shown efficacy in clinical trials for these conditions.
      Obesity and the Skin

      research Obesity and the skin

      128 citations , September 2011 in “British Journal of Dermatology”
      Obesity is linked to various skin problems and may increase the risk of skin cancer.
      Targeting the Janus Kinase Family in Autoimmune Skin Diseases

      research Targeting the Janus Kinase Family in Autoimmune Skin Diseases

      124 citations , October 2019 in “Frontiers in Immunology”
      This review discusses the role of the JAK-STAT pathway in autoimmune skin diseases and suggests potential therapeutic benefits of JAK inhibitors, but reports no new experimental results.
      TRP Channels in Skin Biology and Pathophysiology

      research TRP Channels in Skin Biology and Pathophysiology

      124 citations , December 2016 in “Pharmaceuticals”
      This review discusses the functions and potential therapeutic targeting of TRP ion channels in the skin, noting their involvement in both physiological processes and various pathological conditions, but reports no new experimental results.
      Alopecia Areata: Pathogenesis And Treatment

      research Alopecia areata: Pathogenesis and treatment

      122 citations , November 1984 in “Journal of the American Academy of Dermatology”
      This review discusses the potential autoimmune pathogenesis and various contributing factors of alopecia areata, noting that current treatments remain palliative while emerging therapies offer new hope for extensive cases.
      Hair Regrowth

      research HAIR REGROWTH

      118 citations , April 1998 in “Dermatologic Clinics”
      This review discusses the advancements in understanding and treating androgenetic alopecia and alopecia areata but reports no clinical findings; the authors emphasize the need for further research on molecular control mechanisms.
      Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

      research Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

      102 citations , December 2017 in “˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings”
      This review discusses the role of immune privilege collapse in the pathogenesis of alopecia areata, emphasizing the potential for therapeutic manipulation of hair bulb immune privilege to offer new treatment options, and reports no new results.
      Sigma-1 Receptor-Related Neuroactive Steroids Modulate Cocaine-Induced Reward

      research ς1Receptor-Related Neuroactive Steroids Modulate Cocaine-Induced Reward

      100 citations , May 2003 in “Journal of Neuroscience”
      This study found that neuroactive steroids like DHEA and pregnenolone influence cocaine-induced appetence in mice through their interaction with the ς1 receptor, suggesting a role in individual vulnerability to addiction.
      The Pathogenesis of Alopecia Areata

      research THE PATHOGENESIS OF ALOPECIA AREATA

      89 citations , October 1996 in “Dermatologic Clinics”
      This review discusses androgenetic alopecia and alopecia areata through a systems biology lens, emphasizing the role of multi-omics data integration to explore molecular mechanisms and potential therapeutic strategies, but offers no new clinical results.
      An Integrative View of Mammalian Seasonal Neuroendocrinology

      research An integrative view of mammalian seasonal neuroendocrinology

      85 citations , May 2019 in “Journal of neuroendocrinology”
      This review examines the neuroendocrine mechanisms underlying seasonal changes in mammals and highlights areas needing further research, reporting no new experimental results.
      Polycystic Ovary Syndrome in Adolescence

      research Polycystic Ovary Syndrome in Adolescence

      85 citations , June 2008 in “Annals of the New York Academy of Sciences”
      This article proposes a hypothesis that hyperandrogenemia is the final common pathway for developing adolescent PCOS and emphasizes the importance of reducing androgen levels to mitigate risks of metabolic syndrome, diabetes, and infertility in adulthood.
      Acne

      research Acne

      81 citations , January 2002 in “American journal of clinical dermatology”
      Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.
      What Causes Hidradenitis Suppurativa?—15 Years After

      research What causes hidradenitis suppurativa ?—15 years after

      78 citations , October 2020 in “Experimental Dermatology”
      This review summarizes 15 years of clinical and experimental research advancements in hidradenitis suppurativa, highlighting its recognition as a uniquely healable inflammatory skin disease but reports no new clinical results.
      A Review on Jasmonic Acid and Its Derivatives

      research A Review (Research and Patents) on Jasmonic Acid and Its Derivatives

      75 citations , January 2014 in “Archiv Der Pharmazie”
      This review discusses the synthesis and biological activities of jasmonates, highlighting their potential as drugs and prodrugs, but reports no new clinical results; further research and trials are anticipated.
      Female Gonadal Function Before and After Treatment of Acromegaly

      research Female Gonadal Function before and after Treatment of Acromegaly

      74 citations , July 2010 in “The Journal of Clinical Endocrinology & Metabolism”
      This study found that gonadal dysfunction is very common in premenopausal women with acromegaly and may be caused by hyperprolactinemia, GH/IGF-I excess, or tumor effects.
      Drug Discovery for Alopecia: Gone Today, Hair Tomorrow

      research Drug discovery for alopecia: gone today, hair tomorrow

      70 citations , February 2015 in “Expert Opinion on Drug Discovery”
      This review discusses current knowledge on the biological mechanisms of different types of alopecia but reports no new clinical findings; the authors highlight future research directions, especially regarding epidermal stem cells and immune pathways.
      Alopecia Areata: An Update

      research Alopecia areata: An update

      67 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”
      This review discusses the causes, associated conditions, and treatment options for alopecia areata, such as corticosteroids and wigs, but reports no new clinical findings.
      T Helper 17 Cell/Regulatory T-Cell Imbalance in Hidradenitis Suppurativa/Acne Inversa: The Link to Hair Follicle Dissection, Obesity, Smoking, and Autoimmune Comorbidities

      research T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities

      66 citations , March 2018 in “British journal of dermatology/British journal of dermatology, Supplement”
      This article reviews the role of perifollicular regulatory T cells in maintaining hair follicle integrity in the context of hidradenitis suppurativa and calls attention to inflammatory mechanisms without reporting new clinical results.
      Medical Treatment of Hirsutism

      research Medical treatment of hirsutism

      66 citations , September 2008 in “Dermatologic therapy”
      This review discusses medical treatments for hirsutism, focusing on oral contraceptives and other therapies, but reports no new results; the authors emphasize the lack of evidence for insulin sensitizers in treating hirsutism alone.