40 citations
,
November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the S100A3 gene is exclusively expressed in hair follicle cells differentiating into hair shaft components in mice, suggesting its important role in hair formation.
37 citations
,
May 1998 in “Journal of Dermatological Science” Basal cell carcinoma shows keratin patterns similar to undifferentiated hair follicle cells.
36 citations
,
November 2009 in “Journal of Investigative Dermatology” This study suggests that prolactin has complex, gender- and location-dependent effects on human hair follicles, promoting hair growth in female frontotemporal scalp areas while inhibiting it in male occipital regions.
30 citations
,
December 2019 in “PLoS ONE” This study found that formulating raloxifene in nano-lipid carriers significantly enhanced its permeation and cytotoxicity against cancer cells compared to raw raloxifene.
19 citations
,
December 2015 in “European Journal of Human Genetics” This study found that a novel rare variant in ITGB6 may cause intellectual disability, alopecia, and dentogingival anomalies in a specific Pakistani family, highlighting a potential role for ITGB6 beyond enamel formation.
19 citations
,
March 1998 in “Endocrinology” This study found that sex differences in somatostatin biosynthesis in rat hypothalamic neurons develop between postnatal day 1 and 5, influenced by the conversion of testosterone to estrogen.
17 citations
,
February 2015 in “Cell Death and Disease” This study found that inhibiting AP1 transcription factor activity in the suprabasal epidermis of mice alters keratinocyte gene expression, reducing barrier integrity and mimicking human keratoderma.
16 citations
,
October 2021 in “Trends in biotechnology” This review discusses the potential of protein-based cosmetics, including keratin-based particles and fusion proteins, to improve hair properties such as strength and shape, but it reports no new clinical results.
15 citations
,
July 2002 in “Australasian Journal of Dermatology” In this case report, two plywood mill workers developed allergic contact dermatitis due to exposure to uncured phenol-formaldehyde resin, not sawdust as initially suspected.
14 citations
,
January 2020 in “Evidence-based Complementary and Alternative Medicine” This study found that a newly synthesized peptide from fermented Trapa japonica extract significantly promoted wound recovery and showed antiaging effects in skin cells and a clinical study, suggesting potential as a cosmetic product.
14 citations
,
January 2018 in “Advances in Clinical Chemistry” This review discusses the evaluation of hyperandrogenemia in women and hypogonadism in men across different life stages and presents biomarkers used for diagnosing male hypogonadism, reporting no new clinical results.
14 citations
,
December 2007 in “Pediatric allergy and immunology” In this study, researchers found that mast cells in Erythema Toxicum lesions in newborns are actively involved in the immune response around hair follicles, but do not express the antimicrobial peptide LL-37.
11 citations
,
July 2021 in “Physiologia Plantarum” In this study, the gene SlPHL1 was identified as a transcription factor in tomatoes that enhances phosphate starvation responses by upregulating specific genes.
11 citations
,
May 2018 in “Philosophical Transactions of the Royal Society B” This review covers recent developments in materials for in vitro and in vivo stem cell manipulation, highlighting innovative substrate properties but does not report new experimental results.
11 citations
,
April 2017 in “Journal of The European Academy of Dermatology and Venereology” This study found that long non-coding RNAs are differentially expressed in androgenetic alopecia, suggesting potential roles in its development and novel targets for prevention and treatment.
7 citations
,
December 2020 in “Pharmaceutics” In this study, a mixture of tocopherol acetate, L-menthol, and stevioside was more effective in promoting hair growth in mice compared to tocopherol acetate or L-menthol alone.
7 citations
,
July 2008 in “Experimental Dermatology” This study identified molecular elements controlling the expression and stabilization of THH protein in hair follicle cells, revealing key mechanisms that support hair shaft development in mice.
7 citations
,
July 2005 in “Journal of Dermatological Science” This study identified a gene transcript overexpressed in dermal papilla cells, showing strong similarity to a mouse gene associated with adipose tissue in bombesin receptor subtype-3-deficient mice.
6 citations
,
May 2022 in “Frontiers in physiology” This study suggests that an in ovo injection of CHIR-99021 promoted feather growth and follicle development in goose embryos by activating the Wnt signaling pathway.
6 citations
,
May 2020 in “Scientific reports” In this study, microarray and proteomic analyses indicated that genes involved in immune response, receptor binding, and growth factor activity might influence wool fibre diameter in sheep.
6 citations
,
May 2020 in “Pharmacology Research & Perspectives” This study in rats found that a new hydroxypropyl-β-cyclodextrin formulation of minoxidil reduced the adverse cardiovascular and proliferative effects seen with traditional minoxidil solutions.
6 citations
,
September 2017 in “Experimental and Therapeutic Medicine” This study found that two short peptides derived from pigment epithelium-derived factor significantly accelerated full-thickness skin wound healing in mice through mechanisms that may involve increased cell proliferation and stem cell mobilization.
6 citations
,
January 2013 in “Case reports in endocrinology” This article reviews acromegaloid facial appearance syndrome and presents a case in a 57-year-old woman, emphasizing the need for more cases to understand its clinical features and inheritance patterns.
5 citations
,
May 2021 in “Small ruminant research” This study of Liaoning cashmere goats identified nine keratin proteins as markers of the secondary hair follicle cycle, providing insights that may enhance cashmere quality and production.
5 citations
,
February 2011 in “Expert Opinion on Drug Discovery” This review discusses techniques and models for assessing hair growth activity but reports no new clinical findings, emphasizing the need for standardization and improved animal models.
4 citations
,
June 2021 in “Frontiers in Pharmacology” This study found that injecting bone marrow-derived mesenchymal stem cells and conditioned medium into mice promoted hair follicle stem cell proliferation and transition to active growth phases, suggesting potential clinical targets for hair loss treatment.
4 citations
,
May 2020 in “PLOS ONE” This study found that ingenol mebutate treatment led to gene expression changes in actinic keratoses, with complete lesion clearance in 40% of patients and identified genetic markers potentially predicting treatment response.
4 citations
,
September 2012 in “Journal of dermatological science” The hair follicle's connective tissue is a key source of a certain collagen in human scalp skin.
3 citations
,
October 2024 in “Animals” In this proteomic analysis, the researchers found that transitioning from crimped to straight wool in Tan sheep is linked to significant changes in wool protein expression, revealing distinct patterns of keratins and keratin-associated proteins that could influence wool quality and economic value.
3 citations
,
October 2023 in “Journal of Pain” In this exploratory study of trigeminal neuralgia patients undergoing microvascular decompression surgery, differential protein expression in plasma and cerebrospinal fluid was observed between responders and non-responders, suggesting potential biomarkers to predict surgical success and providing insights into the mechanisms of pain relief.