July 1997 in “Journal of Cutaneous Medicine and Surgery” Finasteride significantly increases scalp hair and prevents hair loss in young and middle-aged men.
June 1997 in “The American Journal of Cosmetic Surgery” This article reviews the role of scalp flap surgery in treating male pattern baldness, noting its advantages such as quick results and increased hair density, though it presents no new clinical findings.
January 1991 in “Journal of Society of Cosmetic Chemists of Japan” In this study, researchers found that specific enzyme activities in young females' hair follicles were correlated with changes in hair shaft structure and properties, and permanent waving was associated with chemical changes that suggest hair damage.
January 2022 in “Aesthetic surgery journal” In this study, intradermal injections of extracellular vesicles over six months were reported to be safe and effective in improving hair growth among patients with pattern hair loss, with favorable response linked to specific patient factors and treatment volumes.
December 2021 in “Egyptian Journal of Dermatology and Venereology” This study found that patients with female pattern hair loss had higher oxidative stress levels and lower antioxidant enzyme activities than healthy controls, suggesting oxidative stress may play a key role in disease progression.
July 2020 in “Bioinformatics and Bioengineering” This study found that multiple genes and pathways, particularly several keratin-associated proteins, may be involved in the molecular pathogenesis of male androgenetic alopecia.
September 2019 in “Journal of Investigative Dermatology” This study found that finasteride treatment reduced urinary androgen and prostaglandin levels in male pattern baldness patients to levels similar to healthy controls.
July 2008 in “British Journal of Dermatology” Cyclosporin doesn't stop hair loss.
694 citations
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April 2000 in “Nature genetics” This study found that Msx2-deficient mice exhibit skull and bone formation defects similar to those seen in human MSX2-related conditions, highlighting the gene's importance in skeletal and organ development.
218 citations
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October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that removing PPARγ specifically from mouse adipose tissue led to severe fat loss, insulin resistance, diabetes, and associated metabolic abnormalities.
193 citations
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February 2015 in “Nature Communications” Fungi-produced compounds can change plant root growth.
100 citations
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September 1999 in “British Journal of Dermatology” This study suggests that finasteride's effect on promoting hair growth in men with androgenetic alopecia may be due to its inhibition of 5aR2 localized in hair follicles.
95 citations
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February 2019 in “The New England Journal of Medicine” This article discusses the potential genetic basis of central centrifugal cicatricial alopecia in women of African ancestry but does not provide new research results.
66 citations
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August 2001 in “Experimental Dermatology” This study demonstrated that intact adult human dermal papillae can induce hair growth when implanted into mouse hair follicles, highlighting their potential for advancing hair follicle biology and therapeutic approaches.
41 citations
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October 2011 in “Clinical and Experimental Dermatology” This meta-analysis suggests that the G allele of AR StuI polymorphism might be a potential risk factor for AGA, particularly in white populations.
38 citations
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June 2019 in “International Journal of Molecular Sciences” This review discusses the potential role of extracellular vesicles in modulating hair follicle dynamics and reports no new clinical results; future investigations may inform treatment strategies for skin disorders.
38 citations
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January 2015 in “Journal of Cosmetic Dermatology” This study found that a 6-month supplementation with omega 3, omega 6, and antioxidants significantly improved hair density and reduced hair loss in women with female pattern hair loss.
36 citations
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July 2014 in “Experimental Dermatology” This narrative piece considers how epigenetic factors may influence the processes of skin wound healing, including hair follicle formation, but it presents no new experimental results.
35 citations
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February 2024 in “Science Advances” This study introduces a magnet-assisted fabrication strategy for creating complex 3D soft bioscaffolds, demonstrating its effectiveness by producing structures with overhangs and supporting biohybrid actuators, promising advancements in biomedical applications.
34 citations
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May 2021 in “Journal of Nanobiotechnology” This study found that electrospun short fibrous sponges effectively mimic the 3D extracellular matrix, promoting tissue regeneration, angiogenesis, and wound healing in diabetic rats better than 2D fiber membranes.
13 citations
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December 2020 in “Dermatologic Therapy” This review discusses the embryology, structure, and function of sebaceous glands and their involvement in skin disorders but reports no novel findings.
12 citations
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January 2014 in “Cell structure and function” This study suggests that specific combinations of human type I and II hair keratins, particularly K35-K85 and K36-K81, have distinct in vitro assembly properties that are significant for macrofibril formation.
9 citations
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June 2020 in “Actas Dermo-Sifiliográficas” This source suggests that spironolactone, a potassium-sparing diuretic, is underutilized in dermatology despite evidence showing its potential benefits for female acne, hidradenitis suppurativa, and female androgenetic alopecia, noting its long-term safety and reduced need for additional testing in young women.
8 citations
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November 2020 in “Frontiers in Cell and Developmental Biology” This study reported that exogenous R-spondin-1 can restore hair follicle neogenesis in adult mouse cells, highlighting differences in gene expression and signaling pathways between fetal and adult dermal papilla cells.
8 citations
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January 2020 in “Biomaterials Science” In this study, small molecule-loaded silk fibroin nanofiber scaffolds with chitosan achieved sustained release of GSK-3 inhibitor SB216763, leading to enhanced wound healing and hair follicle neogenesis in skin regeneration efforts.
8 citations
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July 2014 in “Anais Brasileiros de Dermatologia” This article discusses a case of alopecia areata, androgenetic alopecia, and trichostasis spinulosa, highlighting how dermoscopy can help differentiate black dots from trichostasis spinulosa lesions, but it reports no new clinical results.
5 citations
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January 2022 in “PloS one” This study found that lineage-restricted loss of p63 in murine thymic epithelial cells resulted in severe thymic hypoplasia and absence of hair follicles, indicating p63's critical role in thymic and hair follicle development.
November 2021 in “International Journal of Research in Medical Sciences & Technology” This article reviews optical coherence tomography for skin imaging and its potential clinical uses, but does not include new clinical findings.
September 2021 in “Research Square (Research Square)” This study reports that despite rescuing neurulation and skin barrier defects, Grhl3 gene overexpression in mice leads to hearing impairment, hair loss, and other developmental abnormalities, highlighting low tolerance for Grhl3 dysregulation.
April 2016 in “Journal of Investigative Dermatology” This study suggests that hepatocyte growth factor (HGF) may play a role in hair follicle neogenesis and that an HGF mimetic could enhance skin substitute development.