Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses the mechanisms, symptoms, and body system damage caused by SARS-CoV-2, emphasizing the complexity of treatment and suggesting more research is needed to fully understand COVID-19.

This review discusses the pathogenesis and clinical presentations of alopecia in epidermolysis bullosa patients, noting diverse hair abnormalities and emphasizing the lack of a consensus on its natural history.

This review discusses the immune-mediated mechanism behind alopecia areata, highlighting similarities between the condition in humans and animals, and reports no new clinical results.

This review discusses the factors involved in androgenetic alopecia, emphasizing genetic susceptibility as a key contributor and detailing how follicle miniaturization completes the condition's development; it reports no new clinical results.

This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.

This review discusses rodent models of alopecia areata and suggests they are crucial for understanding the autoimmune mechanisms and potential treatments but reports no new clinical results.

This study found that rare germline pathogenic variants in BRCA2, BRCA1, and ATM are associated with increased risk of aggressive prostate cancer.

This review highlights that fungal co-infections, notably with Aspergillus and Candida, are common in hospitalized COVID-19 patients, but their impact on disease outcomes remains unclear, indicating a need for further research.

Genetics, hormones, and microbiome changes contribute to hidradenitis suppurativa.

Minoxidil solution applied twice daily improved hair growth in patients with Woolly Hair/Hypotrichosis due to LIPH gene issues, with mild side effects.

Scarring alopecia involves increased immune cells and specific gene changes near damaged hair follicles.

Genetic changes in specific proteins contribute to hair loss in some women of African descent.

This article presents a family case study of dermatopathia pigmentosa reticularis linked to a specific KRT14 gene variant, detailing symptoms and stressing the importance of molecular diagnosis for management.

This research suggests that recent discoveries of signaling pathways in androgenic alopecia may pave the way for targeted therapies, providing potential new treatment options beyond the current FDA-approved drugs, minoxidil and finasteride.

This study reports a unique case of coinheritance of BRCA2 and CYLD pathogenic variants in a man with metastatic malignant cylindroma, suggesting that recognizing such genetic profiles in rare conditions can provide new treatment options, including the potential use of therapies targeting BRCA deficiency.

This research explored the roles of various T cell types in chronic alopecia areata, finding that increased severity of lesions and hair loss may be linked to decreased lesional Foxp3+ Tregs, with a notable role for IL-17 and Th17 lymphocytes in the pathological process.

In this study, researchers found that alopecia areata is linked to immune cell activation against hair follicle autoantigens and is associated with heart changes and cardiac marker alterations in humans and mice.

This review discusses the causes, clinical implications, and treatment options for polycystic ovary syndrome and reports no new results; the authors highlight both approved and emerging therapies.

This review discusses androgenetic alopecia and alopecia areata through a systems biology lens, emphasizing the role of multi-omics data integration to explore molecular mechanisms and potential therapeutic strategies, but offers no new clinical results.

This study suggests that intercellular communication via the WNT5A and STAT pathways may partly drive EMT-like phenomena in keloid pathogenesis, based on findings in an animal model.

This case report describes a 41-year-old woman with segmental vitiligo and lichen sclerosus in the perineal region, where treatment with clobetasol ointment improved repigmentation and resolved many symptoms, although some scaling persisted.

Azelaic acid may help treat acne by killing bacteria, reducing inflammation, and preventing clogged pores.

This review systematically evaluates 13 animal and 2 mathematical models for alopecia areata, assessing their effectiveness in understanding the condition's pathogenesis and aiding in the development of new therapeutic strategies.

Schwann cell and M2 macrophage interactions contribute to keloid growth by increasing matrix deposition.

This review article reports that oxidative stress is a key mechanism in the development of androgenetic alopecia, interacting with genetic and hormonal factors to damage hair follicle cells and potentially informing future treatment strategies.

This study observed that the Hedgehog-GLI1 signaling pathway is upregulated in keloid patient–derived stem cells, and inhibiting this pathway reduced keloid characteristics in both mice and ex vivo tissue cultures, suggesting potential therapeutic targets for keloid treatment.

This article reviews the terminology and factors associated with female hair loss, particularly distinguishing it from male pattern hair loss, but reports no new clinical results.

This review discusses genetic factors and associated diseases linked to androgenetic alopecia but reports no new clinical findings.

This review discusses the pathogenesis of alopecia areata, highlighting the role of immune privilege collapse in hair follicles but reports no clinical results.