Pathogenic Th17 Cells, CD8+CD69+CD49a- Tissue-Resident Memory T Cells, and Common γ Chain Receptor+ Natural Killer Cells Express More IL-17 Compared to IFN-γ Under the Foxp3+ Memory Regulatory T Cells-Depleted Microenvironment in Patients with Chronic Alopecia Areata

    April 2023 in “ Journal of Investigative Dermatology ”
    Keon Woo Kim, J. Kim, Y. Cho … Jeremy Yoon
    Studysummary This research explored the roles of various T cell types in chronic alopecia areata, finding that increased severity of lesions and hair loss may be linked to decreased lesional Foxp3+ Tregs, with a notable role for IL-17 and Th17 lymphocytes in the pathological process.
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