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    Did you mean Orthokeratotic Hyperkeratosis?
    Glossary Orthokeratotic Hyperkeratosis

    excessive buildup of outer skin layer without cell nuclei

    Orthokeratotic Hyperkeratosis is a skin condition characterized by an excessive buildup of the outer layer of the skin, known as the stratum corneum, without the presence of nuclei in the keratinocytes. This results in thickened, often scaly skin. For professionals, it is important to note that this condition can be distinguished from parakeratotic hyperkeratosis, where nuclei are retained in the stratum corneum.

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    Research 30 of 509

    1. Intracorneal vacuoles in skin diseases with parakeratotic hyperkeratosis in the dog: a retrospective light‐microscopy study of 111 cases (1973–2000) Veterinary Dermatology · 2002 · 7 citations
    2. Adult-onset porokeratotic eccrine ostial and dermal duct nevus:dermatoscopic findings and treatment with tazarotene Dermatology online journal · 2020 · 7 citations
    3. Porokeratotic eccrine ostial and dermal duct nevus: A noteworthy presentation Indian Dermatology Online Journal · 2015 · 6 citations
    4. Porokeratotic eccrine ostial and dermal duct nevus and porokeratotic eccrine and hair follicle nevus: Is nomenclature “porokeratotic adnexal ostial nevus” more appropriate? Indian Dermatology Online Journal · 2019 · 4 citations
    5. Proliferative, lymphocytic, infundibular mural folliculitis and dermatitis with prominent follicular apoptosis and parakeratotic casts in four Labrador retrievers: preliminary description and response to therapy Veterinary dermatology · 2013 · 10 citations
    6. Proliferative necrotizing otitis externa in two young cats Vlaams dierengeneeskundig tijdschrift · 2023
    7. Pathologic Diagnosis of Central Centrifugal Cicatricial Alopecia on Horizontal Sections American Journal of Dermatopathology · 2014 · 29 citations
    8. Seborrhoeic Dermatitis in Pigmy Goats Veterinary dermatology · 1991 · 5 citations
    9. Hair Casts and Cutaneous Spicules in Multiple Myeloma Archives of dermatology · 2006 · 19 citations
    10. Casts and pseudocasts Journal of the American Academy of Dermatology · 2016 · 8 citations
    11. Hair Dye Effects on the Hair Coat and the Skin of the Dog: A Scanning Electron Microscopic Study Anatomia, Histologia, Embryologia · 1988
    12. Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation Molecular and cellular biology · 2002 · 108 citations
    13. Zinc deficiency in sheep and goats: Three field cases Journal of the American Veterinary Medical Association · 1984 · 45 citations
    14. Evaluation of carcinogenic effect of mineral oil used in the processing of jute fibres. PubMed · 1979 · 8 citations
    15. Skin Lesions in a Daclizumab-treated Patient with Multiple Sclerosis Journal of Interdisciplinary Medicine · 2019 · 1 citations
    16. SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation Cellular and Molecular Immunology · 2026
    17. 489 Seborrhea-like dermatitis phenotype in the Mpzl3 knockout mice 2016
    18. Erythema Multiforme Like Lesions in a Case of Systemic Lupus Erythematosus Turkish Journal of Dermatology · 2012
    19. Porokeratotic adnexal ostial nevus: a paradigm of cutaneous mosaicism Authorea (Authorea) · 2022
    20. Daclizumab Reactions Weekly · 2019
    21. Epidermal Nevi Pediatric Clinics of North America · 2010 · 56 citations
    22. Actinic Hyperkeratosis Treated with Retinol Combined with A Polylysine Biovector: A Case Report ARC Journal of Clinical Case Reports · 2025
    23. Multiple minute digitate hyperkeratosis Journal of the European Academy of Dermatology and Venereology · 2002 · 9 citations
    24. Porokeratotic Eccrine Ostial and Dermal Duct Nevus: A Report of Rare Late-Onset Solitary Lesion Clinical Cosmetic and Investigational Dermatology · 2025 · 1 citations
    25. Is seborrhoeic dermatitis associated with a diffuse, low‐grade folliculitis and progressive cicatricial alopecia? Australasian Journal of Dermatology · 2015 · 15 citations
    26. Granular Parakeratosis of the Eccrine Ostium: A Case Report Clinical Cosmetic and Investigational Dermatology · 2023
    27. Actinic Hyperkeratosis Treated with Retinol Combined with a Polylysine Biovector: A Case Report 2025
    28. CLINICAL, HEMATOLOGICAL AND BIOCHEMICAL STUDIES OF SOME MINERALS DEFICIENCY IN BUFFALOES IN BASRAH,IRAQ Basrah Journal of veterinary Research · 2015
    29. <i>GJB6</i> missense variant in a Labrador Retriever with paw pad hyperkeratosis Animal Genetics · 2026
    30. Obesity and the skin British Journal of Dermatology · 2011 · 128 citations