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Did you mean Orthokeratotic Hyperkeratosis?

GlossaryOrthokeratotic Hyperkeratosis

excessive buildup of outer skin layer without cell nuclei

Orthokeratotic Hyperkeratosis is a skin condition characterized by an excessive buildup of the outer layer of the skin, known as the stratum corneum, without the presence of nuclei in the keratinocytes. This results in thickened, often scaly skin. For professionals, it is important to note that this condition can be distinguished from parakeratotic hyperkeratosis, where nuclei are retained in the stratum corneum.

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research Intracorneal Vacuoles in Skin Diseases with Parakeratotic Hyperkeratosis in Dogs: A Retrospective Light Microscopy Study of 111 Cases (1973–2000)

7 citations , February 2002 in “Veterinary Dermatology”

Intracorneal vacuoles are common in parakeratotic skin diseases in dogs, especially with more parakeratosis.

research Proliferative Necrotizing Otitis Externa in Two Young Cats

February 2023 in “Vlaams dierengeneeskundig tijdschrift”

Two young cats with a severe ear and skin condition improved with immune system-targeting treatments.

research Immunohistochemical Expression of Keratins in Normal Ovine Skin and in Chronic Dermatitis Due to Sarcoptes Scabiei

2 citations , February 2021 in “Journal of comparative pathology”

Sheep with chronic Sarcoptes scabiei dermatitis have altered keratin expression in their skin.

research A Previously Undescribed Cutaneous Paraneoplastic Syndrome in a Cat with Thymoma

2 citations , March 2019 in “Veterinary dermatology”

Thymoma in cats can cause hair loss without inflammation.

research Dermatologic Investigation of Alopecia in Rhesus Macaques (Macaca Mulatta)

29 citations , June 2005 in “Journal of Zoo and Wildlife Medicine”

Most hair loss in captive rhesus macaques is likely due to environmental and behavioral factors.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.