2 citations
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March 2015 in “Human & Experimental Toxicology” This study found that hyperbaric oxygen treatment in rats led to structural changes in epidermis and dermis, including decreased E-cadherin expression and increased connective tissue.
1 citations
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April 2016 in “Journal of Investigative Dermatology” In this study, PGD2 treatment in keratinocytes increased testosterone production via reactive oxygen species, suggesting a potential role for the NRF2 pathway in androgenic alopecia treatment strategies.
September 2026 in “Advanced Materials Technologies” In a mouse model study, researchers developed a methacrylated hyaluronic acid-based hydrogel microneedle patch co-loaded with finasteride and a carbon monoxide-releasing molecule for androgenetic alopecia, which showed better hair regrowth and safety compared to traditional treatments, offering an innovative approach with minimized systemic side effects.
July 2026 in “Journal of Nanobiotechnology” This study describes a multifunctional hydrogel system designed to treat androgenetic alopecia by integrating nanozymes for reactive oxygen species clearance and melanin nano photothermal agents to enhance hair follicle health, suggesting potential for multi-target precision therapy and improved hair growth.
May 2026 in “Journal of the Egyptian Womenʼs Dermatologic Society” This study found that post-COVID-19 telogen effluvium is strongly associated with elevated oxidative stress marker sRAGE and reduced antioxidant marker HO-1, suggesting potential biomarkers for early diagnosis and monitoring.
February 2026 in “Bioengineering” This preliminary study suggests that hyperbaric oxygen therapy may improve scalp health and follicle activation in healthy adults, with subjective assessments showing significant improvements despite mixed objective findings.
February 2026 in “Preprints.org” In this preliminary study, HBOT appeared to improve subjective measures of hair and scalp health in healthy adults, but objective changes in follicle density and hair properties were not statistically significant.
December 2025 in “Regenerative Biomaterials” In this study, researchers developed a responsive bilayer hydrogel for diabetic wounds that delivers drugs and oxygen in sync with healing stages, achieving a 99.1% wound closure rate in 14 days by integrating anti-inflammatory, antibacterial, and anti-fouling functions.
December 2025 in “PubMed” This case study reported that a patient experienced worsening alopecia and scarring after medical ozone therapy, highlighting significant clinical risks that may outweigh potential therapeutic benefits.
December 2025 in “Cureus” This case report found that hyperbaric oxygen therapy significantly accelerated postoperative recovery in hair transplantation patients, improving healing, graft integration, and patient satisfaction without complications.
November 2025 in “Undersea and Hyperbaric Medicine” This case report observed that a patient experienced worsening alopecia and scarring after medical ozone therapy, with subsequent improvement following surgical intervention and systemic hyperbaric oxygenation.
April 2025 in “Journal of Biophotonics” This study found that 808 nm laser photobiomodulation altered mitochondrial respiration and enhanced osteogenic protein expression in human dental pulp stem cells, with the effects being dose-specific and more pronounced at 15 J/cm².
January 2025 in “Skin Pharmacology and Physiology” This study found that alopecia areata patients have elevated oxidative stress markers, such as OSI and MDA, and reduced antioxidant enzyme activities, suggesting a significant role for oxidative stress in the disease and potential value in targeting it therapeutically.
December 2024 in “Journal of Biophotonics” In this study, researchers observed that red and red-orange LED light therapy stimulates nitric oxide production and decreases dihydrotestosterone synthesis in cell models, suggesting a potential mechanism for using light therapy to treat androgenetic alopecia.
October 2023 in “Biomimetics” This study developed a biocompatible hair-dyeing technology using a dark polyphenol complex, which demonstrated effective hair coating, improved mechanical strength, and strong antioxidant properties while maintaining high cell viability.
August 1994 in “Journal of dermatological science” Active oxygen scavengers can reverse the suppression of hair cell growth caused by androgens.
August 2019 in “Chin J Naut Med & Hyperbar Med” This study found that hyperbaric oxygen therapy, when added to conventional treatment for androgenetic alopecia, significantly improved therapeutic outcomes compared to conventional treatment alone.
229 citations
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May 2006 in “Journal of Experimental Botany” This review highlights the role of reactive oxygen species in root hair growth and cell expansion in plants but does not report new empirical findings.
5 citations
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July 2003 in “Pediatric Critical Care Medicine” This study observed that hair loss, which resolved on its own within six months, was reported by some patients after extracorporeal membrane oxygenation, suggesting it as a potential side effect.
2 citations
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November 2017 in “Gynecological Endocrinology” This study found that serum myo-inositol oxygenase levels do not differ between women with polycystic ovary syndrome and healthy controls, suggesting that MI deficiency in PCOS is not due to MIOX levels.
February 2026 in “Frontiers in Medicine” This study suggests that combining LMWHA solution and HCO might improve mild to moderate urinary incontinence in women with GSM, potentially offering benefits over HA therapy alone, but further research is needed.
April 2016 in “Journal of The American Academy of Dermatology” A child on life support experienced rapid hair loss due to severe illness affecting hair growth.
6 citations
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January 1998 in “Journal of Investigative Dermatology” This study found that oxybenzone is very stable under light exposure, contradicting previous findings of its oxidation to semiquinone after solar irradiation.
4 citations
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November 2022 in “Journal of biomedical materials research. Part B, Applied biomaterials” This study demonstrated that human hair keratins have strong antioxidative properties, providing protection against oxidative stress in human dermal fibroblasts, suggesting their potential as antioxidizing supplements.
2 citations
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June 2017 in “Pediatric Dermatology” This case report describes a 2-year-old boy in critical condition who developed anagen effluvium, possibly due to hypotension and hypoxia triggering hair follicle apoptosis.
June 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that a synthetic polyphenol, dimeric 1,2,4-benzenetriol (diBTO), can coat gray hair and gradually oxidize, creating a resistant brown layer similar to apple browning, which offers a practical hair dyeing solution that withstands washing and reduces the need for long dyeing sessions.
May 2024 in “IntechOpen eBooks” In this study, the authors explored the efficacy of hyperbaric oxygen therapy for typical sports injuries and cosmetic surgical wounds, finding that a hormetic dose-response relationship could explain the observed successes, contrary to prevailing expert opinion that deemed this treatment ineffective for normal wounds.
83 citations
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November 2006 in “European Journal of Neuroscience” This study found that progesterone protects rat Purkinje cells during oxygen-glucose deprivation by activating GABA A receptors through its metabolite, allopregnanolone.
16 citations
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November 2011 in “Neuroscience Letters” This study reported that progesterone reduces cell death in hippocampal cultures following oxygen–glucose deprivation mainly through its conversion to allopregnanolone and the involvement of GABAA receptors.
5 citations
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October 2023 in “Phytotherapy Research” This study found that dauricine, a natural compound, may inhibit cell growth and enhance apoptosis in neuroblastoma and glioblastoma by blocking the Oct4/Shh pathway and AKT/β-catenin signaling.