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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Flutamide effectively treats female pattern hair loss with low doses showing good liver tolerance.

Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.

Family members of North Indian women with PCOS have a high rate of metabolic syndrome.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Eating less starch and dairy helped overweight women with PCOS lose weight and improve symptoms.

Oral contraceptives may cause hair loss in women.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Adult female acne requires a comprehensive treatment approach, including medical options and lifestyle changes, with attention to psychological well-being.

Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.

Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.

Small hormonal imbalances can cause significant health problems, so more sensitive testing for hormone-disrupting chemicals is needed.

JAGGED1 could help regenerate tissues for bone loss and heart damage if delivered correctly.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

New therapies are being developed that target integrin pathways to treat various diseases.

Enhancers and super-enhancers are key in controlling specific gene activity and can play a role in cancer development.

Nanoformulations improve luteolin's effectiveness as a cancer treatment.

Decursin shows promise for treating cancer, neuroprotection, inflammation, and hair loss.

Androgen therapy can help with symptoms like low libido in women, but more research is needed to understand its long-term safety and effects on health.

PCOS in lean women is a serious health condition with implications beyond fertility, affecting metabolism and increasing cardiovascular disease risk.

Birth control pills with low-dose estrogen and antiandrogenic progestins can effectively treat acne.

Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.

The document concludes that PCOS in adolescents is complex and requires comprehensive care to manage its symptoms and associated health risks.

Hormonal therapies are safe and effective for treating acne in female adolescents, with specific treatments for those with endocrine disorders.

Early treatment and weight management are important for teenagers with PCOS to reduce symptoms and long-term health risks.