139 citations
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February 2010 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This review outlines the advancements in organ and tissue transplantation since the discovery of the human MHC and reports no new clinical results.
This study found significantly higher P-Smad2 levels in both lesional and nonlesional skin of organ transplant recipients, suggesting elevated TGF-β signaling might contribute to their increased cancer susceptibility.
77 citations
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April 2016 in “Science Advances” Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.
May 2026 in “Case Reports in Dermatology” This case report detailed a 31-year-old kidney transplant recipient who experienced significant hair loss linked to tacrolimus-based immunosuppression, which improved after switching to cyclosporine A, emphasizing the importance of awareness and management of hair-related side effects in transplant patients.
This case report highlights hair loss as a side effect of tacrolimus-based immunosuppression in a kidney transplant patient, improving after switching to cyclosporine A. The authors emphasize the importance of monitoring and managing such side effects to ensure treatment adherence and patient well-being.
This case report from a kidney transplant patient highlights significant alopecia linked to tacrolimus-based immunosuppression, with improvement seen after switching to cyclosporine A, emphasizing the importance of monitoring and managing hair loss to support treatment adherence and patient quality of life.
January 2025 in “Advances in Dermatology and Allergology” This review highlights a gap between patient-reported and physician-perceived rates of alopecia in transplant recipients, suggesting the issue may be underestimated and stressing the need for better recognition and management of hair disorders caused by immunosuppressive therapy post-kidney transplantation.
March 2025 in “JAAD International” Alopecia areata is rare in organ transplant patients and may be linked to the drug tacrolimus.
September 2023 in “Journal of the American Academy of Dermatology” Alopecia is rare after organ transplants but more common in females, Hispanic patients, and pancreas recipients.
66 citations
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May 2012 in “Scientific Reports” This study demonstrated that bioengineered hair follicles reconstituted from embryonic skin cells and transplanted into hosts can restore physiological hair functions, suggesting potential applications for treating alopecia.
April 2023 in “American Journal of Transplantation” This study found that hormone replacement therapy was associated with reduced COVID-19 mortality and adverse outcomes in nonimmunosuppressed postmenopausal women and immunocompromised male solid organ transplant recipients.
25 citations
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August 2024 in “Virtual and Physical Prototyping” This review outlines various 3D bioprinting techniques and bioinks used for creating artificial tissues and organs, emphasizing their potential in addressing organ transplant shortages and advancing drug testing, while acknowledging existing challenges and future prospects.
165 citations
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October 2013 in “Nature Communications” This study demonstrates that bioengineered salivary gland transplants can fully regenerate gland function, producing saliva and restoring normal swallowing in salivary gland-defective mice, offering potential for xerostomia treatment.
256 citations
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October 2013 in “Nature Communications” This study demonstrates that bioengineered lacrimal gland germs can successfully develop and restore tear production and ocular surface protection in a mouse model with lacrimal gland dysfunction.
7 citations
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August 2025 in “European Journal of Endocrinology” The authors concluded that incorporating routine endocrinology consultations into transplant care could address CNI-related endocrine toxicities, but prospective studies are needed to assess the impact on graft and patient survival.
February 2026 in “Biochemical and Biophysical Research Communications” This study identifies a specific cell population, PDGFRα+/Sca1+/CD34+ mesenchymal cells, which play a crucial role in regenerating hair follicles by promoting the downgrowth phase of the hair cycle, offering insights into organ morphogenesis and stem cell niches essential for adult hair regeneration.
18 citations
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January 2013 in “International Society of Hair Restoration Surgery” This article discusses the importance of clinical biopreservation for cells and tissues in hair transplantation and regenerative medicine, reporting no new empirical findings.
6 citations
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January 2016 in “Methods in molecular biology” This protocol describes a method for regenerating hair follicles using a bioengineering technique called the Organ Germ Method, but it reports no new clinical results.
12 citations
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April 2019 in “Nature protocols” This study describes a protocol for generating a fully functional 3D integumentary organ system from murine induced pluripotent stem cells, including the formation of hair follicles and sebaceous glands that function in vivo.
May 1991 in “Current problems in dermatology” This article reviews the relationship between the skin and the immune system and discusses how skin manifestations can indicate immunodeficiencies but reports no new research findings.
October 2022 in “Experimental Dermatology” This review discusses the development of hair-on-a-chip technology for hair follicle research and alopecia treatment, reporting no new clinical results but highlighting future research directions.
January 2017 in “Springer eBooks” This review discusses recent advancements in hair follicle regeneration technologies, including the authors' own development of functional hair regeneration through bioengineered follicle germ transplantation, but reports no new clinical results.
2 citations
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January 2015 in “Nihon Rinshō Men'eki Gakkai kaishi” This review discusses regenerative therapy approaches, such as tissue stem cell transplantation and gene therapy, for restoring salivary gland function in xerostomia and reports no new research results.
January 2010 in “Actas Dermo-Sifiliográficas” A woman developed thick gums from everolimus treatment after a kidney transplant.
October 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the proprietary aptamer TAGX-0003 significantly inhibited IFNγ-induced effects in pre-clinical human models of alopecia areata, promoting hair regrowth and potentially preventing disease relapse.
April 2026 in “Reviews in Medical Virology” This review discusses recent updates on trichodysplasia spinulosa, focusing on its seroepidemiology, mechanisms, and treatment options, and reports no new clinical results.
2 citations
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October 2019 in “Nanomedicine” This commentary discusses current challenges and future opportunities in pharmaceutical care for organ transplant recipients, focusing on immunosuppressive strategies, their complexities, and potential advancements like nanoimmunotherapy, but reports no new clinical results.
September 2018 in “Journal of Investigative Dermatology” Non-white organ transplant patients have worse skin cancer outcomes due to later diagnosis and treatment.
21 citations
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October 2009 in “Biochemical Engineering Journal” This review discusses various approaches to treating alopecia, including drug therapy and hair transplantation, but reports no new research findings; the authors highlight the need for novel techniques like cell culturing.
22 citations
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March 2017 in “Transplant Infectious Disease” This case report describes successful treatment of generalized trichodysplasia spinulosa with leflunomide in a patient undergoing immunosuppressive therapy following solid organ transplantation.