1 citations
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June 2021 in “Biomolecules & Therapeutics” In this study, researchers found that activating the delta opioid receptor with a specific agonist significantly promoted hair growth in mice, suggesting potential for developing new hair-loss treatments.
67 citations
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September 2001 in “American Journal Of Pathology” This study found that overexpression of the enzyme ornithine decarboxylase in transgenic mice led to UVB-induced skin tumors, but this was prevented by the ODC inhibitor α-difluoromethylornithine.
2 citations
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January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that low temperatures and nitrogen deficiency trigger root hair elongation through a molecular mechanism involving the receptor kinase FERONIA and the TOR Complex 1.
September 2018 in “Cosmetics” This study found that anisotropic osmolyte solutions may improve hair follicle turnover and condition in both in vitro and in silico models, as well as in human volunteers with hair disorders.
1 citations
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December 2022 in “Genes” This study found that recombinant oleosin-hFGF5 expressed in Arabidopsis can inhibit hair regeneration by decreasing the proliferation of hair follicle epithelial cells.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This narrative literature review by Lustrao examines the existing research on six botanical ingredients in their Hair Regrowth Oil, finding varied evidence levels and highlighting rosemary oil's strong human clinical support for hair growth compared to minoxidil.
3 citations
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February 1983 in “Journal of Investigative Dermatology” This study found that plucking hair from rats' dorsal skin rapidly decreased ornithine decarboxylase activity, possibly due to an inhibitory substance that was activated by ammonium sulfate treatment.
11 citations
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October 2017 in “International Journal of Molecular Sciences” In this study, oil body-bound oleosin-rhFGF-10 was more efficiently absorbed through the skin and enhanced wound healing and hair growth in mice, compared to prokaryotically-expressed rhFGF-10.
2 citations
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February 2022 in “Research Square (Research Square)” This study found that the ethanolic root extract of Onosma dichroantha exhibits antioxidant activity and significant antimicrobial effects against 11 bacterial species.
9 citations
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December 2014 in “Daehan miyong hakoeji” Peppermint oil promotes hair growth and fights bacteria better than minoxidil.
11 citations
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December 2021 in “Journal of Ginseng Research/Journal of ginseng research” This review discusses the chemical composition, potential health benefits, and extraction methods of red ginseng oil, and reports no new clinical results but emphasizes safety and proposed molecular mechanisms.
15 citations
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July 2015 in “Developmental Dynamics” This study highlights the role of Orai1 in ameloblast differentiation and maturation, showing that its down-regulation affects cell proliferation and enamel formation during tooth development.
4 citations
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November 2024 in “Cell Biology and Toxicology” This study suggests that targeting olfactory receptors in the lung epithelium might help treat odorant-induced asthma in cases without type 2 inflammation, as these receptors could play a role in airway sensitivity to smells.
June 2025 in “Biomolecules” In this study, researchers found that activating RORA in hair follicle stem cells reduced the expression of cytoskeleton-related genes, affecting cell migration and adhesion, which may aid in understanding hair follicle development and potentially inform alopecia treatments.
April 2018 in “Journal of Investigative Dermatology” This study identified the osteopontin-derived peptide, FOL-005, as a potential inhibitor of unwanted human hair growth by promoting catagen development without reducing stem cell numbers or showing toxicity.
44 citations
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January 2023 in “New Phytologist” This study found that low temperature triggers root hair elongation in Arabidopsis thaliana through a FERONIA-ROP2-TORC signaling pathway, also activated by nitrogen deficiency.
August 2023 in “The Indonesian Biomedical Journal” This study on UVB-exposed mice found that topical application of 10% Rosmarinus officinalis essential oil significantly increased hair length and follicle diameter, attributed potentially to its antioxidant compounds.
December 2015 in “Focus on catalysts” This study found that Pomiferin demonstrated potent stimulation of extracellular matrix proteins in human dermal fibroblasts and hair follicles, suggesting its potential as an ingredient in skin and scalp treatments.
25 citations
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September 2018 in “Scientific Reports” This study found that morroniside enhanced hair follicle growth and transition through the Wnt/β-catenin signaling pathway in a mouse model, suggesting its potential as a treatment for hair loss.
37 citations
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January 1986 in “Carcinogenesis” This study found that TPA treatment transiently induces high levels of ODC in mouse epidermal cells, particularly around hair follicles, with localization reduced by retinoic acid or cycloheximide pretreatment.
December 2015 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that minoxidil sulfate enhanced hair growth in CRF-OE mice, with increased hair growth scores observed at 2 and 4 weeks after treatment.
4 citations
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January 1988 in “Cosmetics and toiletries” 0.1% piroctone olamine in hair tonics effectively treats dandruff.
April 2026 in “Amino Acids” This study reviews prior research using transgenic K6/ODC mice and demonstrates that elevated polyamines in epithelial cells contribute significantly to skin tumor development and progression by stimulating proliferation, altering cell signaling and chromatin remodeling, and affecting immune functionality, amongst other mechanisms.
June 2026 in “Scientific Reports” This study identified hypericin and berberine as compounds that can support hair growth by enhancing oxytocin receptor expression and acting as an oxytocin receptor agonist, respectively, potentially serving as practical alternatives to oxytocin for treating hair-loss diseases.
8 citations
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August 2014 in “Biochemical and Biophysical Research Communications” The study found that over-expressing ornithine decarboxylase in the outer root sheath of the hair follicle in mice increases UVB-induced tumor growth and invasive squamous cell carcinoma compared to inter-follicular epidermal keratinocytes.
2 citations
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April 2021 in “Asian pacific Journal of Tropical Biomedicine” This study found that Origanum vulgare extract significantly ameliorated finasteride-induced liver and kidney damage in mice by improving biochemical indices, reducing inflammation, and enhancing antioxidant status in a dose-dependent manner.
65 citations
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March 2004 in “Journal of Clinical Investigation” In this study, overexpression of ornithine decarboxylase accelerated basal cell carcinoma in Ptch1+/– mice under UVB exposure, while its inhibition reduced tumor induction, suggesting potential chemoprevention strategies in humans.
30 citations
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December 2014 in “Toxicological Research” This study found that 3% peppermint oil significantly enhanced hair growth in C57BL/6 mice, showing increased dermal thickness, follicle number, and follicle depth compared to other treatments.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This narrative literature review by Lustrao synthesizes existing research on six botanical ingredients used in Lustrao Hair Regrowth Oil, noting varying evidence levels with rosemary oil showing the clearest human clinical support for hair growth, particularly against minoxidil.
33 citations
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September 2017 in “Molecules” This study found that red ginseng oil and its major components improved hair regrowth in testosterone-treated mice by promoting an earlier anagen phase and altering related gene expressions.