The Remarkable Legacy of the K6/ODC Mouse: Mechanisms of Polyamine-Promoted Tumorigenesis Revealed

April 2026 in “ Amino Acids ”

Susan K. Gilmour

TLDR Polyamines are crucial for skin tumor development, and inhibiting them can prevent tumors.

The K6/ODC mouse model, developed 30 years ago, has been instrumental in understanding the role of polyamines in skin tumorigenesis. By expressing the enzyme ornithine decarboxylase (ODC) in hair follicle cells, researchers demonstrated that polyamines are crucial in the early stages of tumor development. Inhibiting ODC activity was shown to prevent and regress skin tumors. The model revealed that elevated polyamines in epithelial cells promote proliferation, invasiveness, stem cell recruitment, chromatin remodeling, metabolic reprogramming, increased vascularization, fibroblast activation, and immune cell function alterations, all of which contribute to tumor development and progression.

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