Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System That Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice

The document from 2017 details a study on a novel drug delivery system using oil body-bound oleosin-rhFGF-10 to enhance skin penetration, wound healing, and hair growth in mice. The researchers created a fusion protein in genetically engineered safflowers and applied it topically to mice. This treatment showed improved wound healing and hair growth compared to the control and regular rhFGF-10 treatments. The oleosin-rhFGF-10 group exhibited over 90% hair coverage at day 15, which was significantly higher than the control groups. The study also found that oleosin-rhFGF-10 is stable and resistant to proteolysis, making it a promising drug for skin wounds and hair loss treatment in humans. The study involved groups of six mice for each treatment and included various experimental procedures such as PCR, Southern blotting, ELISA, and histological analysis.