Expression of Oleosin-rhFGF9 Fusion Protein in Carthamus Tinctorius and Determination of Hair Regeneration and Wound Repair Potential in Mice

The study investigated the expression of a recombinant fusion protein, oleosin-rhFGF9, in Carthamus tinctorius (safflower) and its effects on hair regrowth and wound repair in mice. The oleosin-rhFGF9 gene was successfully introduced into safflower plants, and the resulting transgenic safflower oil expressed the fusion protein. Sixty C57BL/6 mice were used to test the efficacy of the transgenic safflower oil on hair regrowth and wound healing, with groups receiving different treatments including a control, a negative control with wild-type safflower oil, a positive control with FGF9, and low and high doses of the transgenic oil. The results showed that the high dose group had significantly better hair regrowth and wound healing compared to the positive control group. The study concluded that the transgenic safflower oil bodies expressing oleosin-rhFGF9 have potential in promoting hair regeneration and wound repair.