January 2023 in “Han'gug mi'saengmul saengmyeong gong haghoeji/Han-guk misaengmul saengmyeong gonghak hoeji” This study found that a mixed extract of N. jatamansi, O. basilicum, and C. sativus, particularly when extracted via steaming and ultrasonic methods, increased antioxidant content, stimulated melanin production for black hair, and promoted hair growth in mouse models, while maintaining high cell viability.
June 2014 in “Zagazig Journal of Pharmaceutical Sciences/Zagazig Journal of Pharmaceutical Science” This study reports that using ascorbic acid or orlistat can significantly inhibit the metabolism of testosterone esters into malodorous metabolites by axillary bacteria, suggesting potential new deodorant applications.
1 citations
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January 2025 in “RSC Advances” The researchers evaluated scientific data on the usage and pharmaceutical applications of ascorbic acid derivatives, such as ascorbyl-6-palmitate and ascorbyl-2-glucoside, highlighting their development into stable delivery platforms to overcome ascorbic acid's instability and formulation challenges.
August 2024 in “Biomedical Journal of Scientific & Technical Research” This review discusses the role of steroid 5 alpha reductase 2 in converting testosterone to DHT and its association with conditions like benign prostatic hyperplasia and prostate cancer; it reports no new results.
September 2021 in “Journal of skin and stem cell” Lactium, a milk protein, can help reduce symptoms of skin disorders linked to stress and anxiety without side effects.
This study found that the methanolic heartwood extract of Avicennia marina significantly inhibited the enzyme 5 alpha-reductase type 1 in a cell-based assay, suggesting potential anti-androgenic effects for treating androgenic alopecia.
July 2025 in “ACS Pharmacology & Translational Science” In this study, maslinic acid applied topically was observed to stimulate hair growth in mice comparably to minoxidil, primarily activating pathways like Wnt/β-catenin, and suggesting a link between hair growth and cilia activity.
August 2026 in “Revista Brasileira de Farmacognosia” Sea holly extract may help reduce hair loss.
March 2016 in “West Indian medical journal” This study found no statistically significant relationship between androgenic alopecia and the PON1 ML55 and QR192 genetic polymorphisms, despite a higher frequency of the PON 55 L allele in patients.
1 citations
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January 1980 in “Acta Dermato Venereologica” This study found that oral tetracycline hydrochloride significantly reduced the free fatty acid/triglyceride ratio in hair lipids of young men and women treating acne vulgaris, with or without additional ethyl lactate application.
3 citations
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March 2016 in “Phytotherapy Research” In laboratory tests, this study found that a novel natural composition targeting 5-alpha reductase and inflammatory pathways reduced disease-related markers in androgenetic alopecia and benign prostatic hyperplasia more effectively than finasteride.
5 citations
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October 2024 in “International Journal of Molecular Sciences” This study observed that piperonylic acid activated key signaling pathways in dermal papilla cells and increased hair growth markers, and a clinical trial showed users of a piperonylic acid formulation had more hair than those using a placebo, suggesting its potential for treating hair loss.
7 citations
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January 2022 in “Scientific Reports” This study found that Acanthus ebracteatus extract and verbascoside induced dermal papilla cell proliferation and reduced inflammatory cytokine release in vitro, suggesting potential for anti-hair loss applications.
This study mapped potential targets and pathways for baicalin's action in androgenic alopecia, suggesting it may inhibit 5α-reductase and serve as an effective treatment ingredient.
25 citations
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September 2014 in “Biological Research” This study found that arctiin, a compound from Arctium lappa, demonstrated protective effects against oxidative stress-induced dysfunction in human hair dermal papilla cells, suggesting potential therapeutic use for alopecia.
4 citations
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November 2021 in “Pharmaceuticals” This study found that Paeonia lactiflora and Poria cocos extracts promoted hair regrowth in a mouse model of androgenetic alopecia, with similar effects observed to normal controls.
December 2022 in “Research Square (Research Square)” This study found that an extract from the herbal medicine Ophioglossum vulgatum Linn. showed potential hair growth promotion and increased ATP and catalase activity in cell assays, suggesting its use in treating alopecia.
5 citations
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July 2017 in “Molecular Medicine Reports” This study observed that ethanol extracts of Lygodium japonicum spores significantly reduced inflammatory responses in LPS-stimulated murine macrophages in vitro by negatively regulating p38 MAPK and NF-κB.
38 citations
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November 2016 in “Aaps Pharmscitech” This study found that the nanostructured lipid carrier formulation with a 70:30 solid to liquid lipid ratio significantly increased the dissolution rate, entrapment efficiency, and stability of spironolactone compared to its raw form.
In this study, Origanum vulgare extracts showed antioxidant activity and increased insulin-like growth factor-1 expression without causing cytotoxicity in human hair dermal papilla cells.
January 2017 in “Anais do 5º Encontro Brasileiro para Inovação Terapêutica” This study found that Dysphania ambrosioides oil exhibited cytotoxicity against U-937 lymphoma cells, indicating potential activity that warrants further investigation.
May 2025 in “Insights-Journal of Health and Rehabilitation” This study found that Aloe vera and Citrus lemon extracts demonstrated notable antibacterial effects against Propionibacterium acnes in both lab and human skin models, with combined use resulting in a 67% reduction in acne, suggesting potential for future therapeutic applications.
17 citations
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August 2012 in “Archives of Pharmacal Research” Acankoreoside J from Acanthopanax koreanum may help promote hair growth.
May 2021 in “Research Square”
1 citations
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January 2020 in “Indo global journal of pharmaceutical sciences” This article reviews the traditional uses of Citrullus colocynthis for various conditions like cancer and jaundice but reports no new clinical results, underscoring its role in folk medicine.
104 citations
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January 2016 in “Food & Function” This review found that olive oil phenols may have anti-cancer properties in animal models and some human studies, but further research is needed to confirm these effects in humans.
22 citations
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May 2003 in “Planta Medica” This study found that torilin from Torilis japonica fruit extract inhibited 5 alpha-reductase in vitro more effectively than alpha-linolenic acid but less effectively than finasteride.
12 citations
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July 2017 in “International Journal of Cosmetic Science” This study found that N‐AOHPA was particularly effective as a silicone emulsifier for improving the condition of damaged hair by preventing amino acid dissolution from bleached hair.
June 2020 in “International journal of research in dermatology” This study found that oral intake of choline-stabilized orthosilicic acid (ch-OSA®) significantly improved hair, skin, and nail health in the Indian population, with no reported side effects.
7 citations
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August 2024 in “Marine Drugs” This study found that ultrasonically depolymerized ι-carrageenan from Solieria chordalis yields low-molecular-weight fractions that maintain fibroblast viability and show no cytotoxicity, suggesting potential for safe use in human medicine.