research How Our Microbiome Influences the Pathogenesis of Alopecia Areata
Our microbiome may affect the development of the hair loss condition Alopecia Areata, but more research is needed to understand this relationship.
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research Treatment of Alopecia Areata in Mice by Stimulating Hair Follicles Using Parathyroid Hormone Agonists Linked to a Collagen Binding Domain
A protein combining parathyroid hormone and collagen helped hair regrow in mice with a hair loss condition.
research Understanding Autoimmunity of Vitiligo and Alopecia Areata
Both vitiligo and alopecia areata involve an immune response triggered by stress and specific genes, with treatments targeting this pathway showing potential.
research Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.
research Alopecia Universalis Treated With Tofacitinib: The Role of JAK/STAT Inhibitors in Hair Regrowth
Tofacitinib helped a woman with total-body hair loss grow her hair back.
research New Modalities in the Treatment of Refractory Alopecia Areata
New treatments focusing on immune pathways show promise for stubborn hair loss.
research Cutaneous Manifestations Associated With Immune Checkpoint Inhibitors
Immune checkpoint inhibitors can cause skin issues but are linked to better cancer outcomes.
research Special Stains and Immunohistochemical Stains in Hair Pathology
Special and immunohistochemical stains are not routinely needed for diagnosing hair disorders.
research Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration
Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.
research MTOR Signaling in Hair Follicle and Hair Diseases: Recent Progress
The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.
research 2-Deoxy D-Glucose Treatment Does Not Elicit a Hair Growth Response in Alopecia Areata
2-deoxy D-glucose does not help with hair regrowth in alopecia areata.
research CCR5 Blockade Shows Prevention of Alopecia Areata Development as Well as Improvement of Alopecia Areata
Blocking CCR5 can prevent and improve hair loss in alopecia areata.
research Glycogen Metabolism and Cori Cycle in Human Hair Follicles
Human hair follicles have a unique way of using energy and might use the Cori cycle; blocking CCR5 could help treat hair loss.
research Loss of Langerhans Cells in Scar Lesion of Lichen Planopilaris Is Caused by Downregulation of Integrin αvβ6 in the Epidermal Keratinocytes
Scarred skin in lichen planopilaris loses immune cells due to a decrease in a specific protein in skin cells.
research Current Protocols: Alopecia Areata Mouse Models for Drug Efficacy and Mechanism Studies
The C3H/HeJ mouse model is useful for studying and testing treatments for alopecia areata.
research (-)-Cannabidiol Differentially Influences Hair Growth
CBD can either promote or inhibit hair growth depending on the concentration used.
research Emerging Drugs for Alopecia Areata: JAK Inhibitors
JAK inhibitors may soon be a safe and effective treatment for alopecia areata.
research Pharmacological Treatment of Alopecia
Only minoxidil and finasteride are FDA-approved for hair loss, with other treatments available but less effective or with side effects.
research Hair Pathology
Triple horizontal scalp biopsies are 98% accurate in diagnosing hair loss, better than single biopsies.
research Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles
Certain genetic variants linked to immune response increase the risk of alopecia areata in Taiwanese people.
research Targeting Pathogenic MICA-NKG2D Interactions by Statins: A Novel Adjunct Treatment Strategy for Alopecia Areata Management?
Statins may help treat alopecia areata by reducing harmful immune interactions.
research Endoplasmic Reticulum Stress Upregulates NKG2D Ligands in the Hair Follicle
Stress in hair follicle cells increases certain immune-related proteins, which might contribute to hair loss conditions.
research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity
Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.
research The PDE4 Inhibitor, Apremilast, Suppresses Experimentally Induced Alopecia Areata in Human Skin In Vivo
Apremilast may help treat hair loss in alopecia areata.
research Treatment of Alopecia Areata: What Is New on the Horizon?
New treatments for alopecia areata may target specific immune cells and pathways involved in hair loss.
research Simvastatin Reduces Autoimmune Alopecia Through Direct Action on T Lymphocytes
Simvastatin helps hair regrowth in autoimmune alopecia by directly affecting T cells.
research Vδ1+ T-Cells Are Stress-Sentinels in Human Skin and Are Implicated in Alopecia Areata Pathogenesis
Vδ1+ T-cells in the skin contribute to hair loss in alopecia areata and could be targeted for treatment.
research IKZF1 and IKAROS Overexpression Contributes to the Pathogenesis of Alopecia Areata
Too much IKZF1 and Ikaros protein may cause alopecia areata.
research Simvastatin Decreases Alopecia Areata-Associated Inflammation Through Effects on Isoprenoid Metabolites
Simvastatin reduces inflammation and promotes hair regrowth in alopecia areata.
research An Immune Regulatory CCT Repeat Containing Oligodeoxynucleotide Capable of Causing Hair Loss in Male Mice
A specific DNA sequence caused hair loss in male mice by activating immune cells and increasing a certain immune signal.