Exploring the Gut Microbiome and Metabolome in Individuals with Alopecia Areata

This study analyzed the gut microbiome and metabolome in 24 Alopecia Areata (AA) patients and 18 healthy individuals (HI). Results showed AA patients had reduced species richness and evenness in their gut microbiota, with specific microbial biomarkers like increased Blautia and decreased Coprococcus. Metabolite analysis identified potential proinflammatory markers, such as branched chain fatty acids and amino acids, in AA patients. Despite no significant differences in overall microbiota composition, the findings suggest a link between gut dysbiosis and AA, proposing that targeting the gut microbiome could be a therapeutic strategy for AA.