Exploring the Gut Microbiome and Metabolome in Individuals with Alopecia Areata

March 2024 in “ Nutrients ”

Olga Nikoloudaki, Daniela Pinto, Marta Acín-Albiac, Giuseppe Celano, Alessio Da Ros, Maria De Angelis, Fabio Rinaldi, Alessio Da Ros, Raffaella Di Cagno

Alopecia Areata gut microbiome metabolome Blautia Coprococcus branched chain fatty acids amino acids gut dysbiosis AA

TLDR Alopecia Areata is linked to specific gut bacteria and metabolites, indicating a complex gut microbiome.

This study analyzed the gut microbiome and metabolome in 24 Alopecia Areata (AA) patients and 18 healthy individuals (HI). Results showed AA patients had reduced species richness and evenness in their gut microbiota, with specific microbial biomarkers like increased Blautia and decreased Coprococcus. Metabolite analysis identified potential proinflammatory markers, such as branched chain fatty acids and amino acids, in AA patients. Despite no significant differences in overall microbiota composition, the findings suggest a link between gut dysbiosis and AA, proposing that targeting the gut microbiome could be a therapeutic strategy for AA.

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Exploring the Gut Microbiome and Metabolome in Individuals with Alopecia Areata

Research cited in this study

research Oxidative Stress and Alopecia Areata

research Comparative Analysis of Scalp and Gut Microbiome in Androgenetic Alopecia: A Korean Cross-Sectional Study

research How Our Microbiome Influences the Pathogenesis of Alopecia Areata

research Lichen Planopilaris: First Biopsy Layer Microbiota Inspection

research A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: Staphylococcus Caprae, Corynebacterium, and Cutibacterium Species

research Gut Microbiota in Alopecia Areata

research Implication of Human Bacterial Gut Microbiota on Immune-Mediated and Autoimmune Dermatological Diseases and Their Comorbidities: A Narrative Review

research Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata

research Alopecia Areata and the Gut: The Link Opens Up for Novel Therapeutic Interventions

research Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

research Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata

research Probing the Effects of Stress Mediators on the Human Hair Follicle

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