Implication of Human Bacterial Gut Microbiota on Immune-Mediated and Autoimmune Dermatological Diseases and Their Comorbidities: A Narrative Review

The review from January 2021 discussed how modern sequencing methods have advanced our understanding of the human gut microbiome and its role in maintaining physiological functions, particularly in regulating the immune system. It highlighted that an imbalance in the gut microbiota, known as dysbiosis, is associated with autoimmune and immune-mediated dermatological conditions such as systemic lupus erythematosus, atopic dermatitis, psoriasis, and alopecia areata. The review also noted that specific gut microbial signatures might correlate with the clinical outcomes and prognoses of these diseases. The potential for gut microbiota composition to influence the clinical course of these conditions and their comorbidities was considered, suggesting that a deeper understanding of gut microbiota could lead to new treatments and the ability to predict disease progression and associated comorbidities.